bimolane
National Institutes of Health
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To the Editor,
Therapy-related acute myeloid leukemia (t-AML) typically occurs after exposure to alkylating agents…
AIM
To study the genotoxicity of bimolane.
METHODS
Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate…
Bimolane, 1,2-bis(4-morpholinomethyl-3,5-dioxopiperazinyl) ethane, is a new antineoplastic agent synthesized first in China. The…
The isolated rat liver mitochondria were used in vitro to study the effect of doxorubicin on lipid peroxidation. We found that…
Bimolane, an analog of razoxane has been used in China with comparable efficacy but less toxicity than razoxane in the treatment…
By means of liquid scintillation spectrometry. the effects of bimolane (AT-1727) and probimane (AT-2153) on the incorporation of…
It was reported that bimolane [AT1727; bis (N4-mopholino-methyl-3,5- dioxopiperazynyl)-l,2-ethane] could be used as a…
X-ray diffraction studies of crystals from samples of bimolane synthesized in China and in the United States showed that the…