axitinib

Known as: N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, axitinibum 
An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Population pharmacokinetic data suggest axitinib plasma exposure correlates with efficacy in metastatic renal-cell… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Axitinib is a potent, selective inhibitor of vascular endothelial growth factor (VEGF) receptors 1, 2, and 3. A… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE To evaluate if diastolic blood pressure (dBP) ≥90 mm Hg during axitinib treatment is a marker of efficacy. EXPERIMENTAL… (More)
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Review
2010
Review
2010
The vascular endothelial growth factor (VEGF)/VEGF receptor tyrosine kinase (RTK) signaling pathway plays a pivotal role in tumor… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE To investigate the efficacy and safety of axitinib, an oral, potent, and selective inhibitor of vascular endothelial… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE This phase II study evaluated efficacy and safety of single-agent axitinib, an oral, potent, selective inhibitor of… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Patients with advanced, incurable thyroid cancer not amenable to surgery or radioactive iodine ((131)I) therapy have few… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Axitinib (AG-013736) is a potent and selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Axitinib (AG-013736) is a potent and selective oral inhibitor of vascular endothelial growth factor receptors 1, 2… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Axitinib (AG-013736) is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1, 2… (More)
Is this relevant?