Indazoles

Known as: Indazoles [Chemical/Ingredient] 
 
National Institutes of Health

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3-indazolinone4-aminonigellidine5,7-dinitroindazole5-aminoindazole
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In Bloodagonistsantagonists & inhibitorschemical synthesis
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Papers overview

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2016
2016
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing… (More)
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2011
2011
Discovery of indazoles as inhibitors of Tpl2 kinase.
Synthesis, modeling and structure-activity relationship of indazoles as inhibitors of Tpl2 kinase are described. From a high… (More)
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2011
2011
Binding studies and quantitative structure-activity relationship of 3-amino-1H-indazoles as inhibitors of GSK3β.
Docking of 3-amino-1H-indazoles complexed with glycogen synthase kinase 3 beta (GSK3β) was performed to gain insight into the… (More)
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2008
2008
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
A series of substituted 2-benzyl-3-aryl-7-trifluoromethylindazoles were prepared as LXR modulators. These compounds were partial… (More)
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2008
2008
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide… (More)
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2007
2007
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
A series of 3-aroyl indazoles was synthesized. Modification of the C-7 position resulted in a significant structure-activity… (More)
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2007
2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
2,4-Dianilino pyrimidines are well-known inhibitors of tyrosine kinases including lymphocyte specific kinase (Lck). Structure… (More)
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1994
1994
The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agents.
Citrulline formation by Ca(2+)-calmodulin (CaM)-dependent nitric oxide synthase from bovine brain is inhibited reversibly by… (More)
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Highly Cited
1993
Highly Cited
1993
Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects.
1. 7-Nitro indazole (7-NI, 10-50 mg kg-1), 6-nitro indazole and indazole (25-100 mg kg-1) administered i.p. in the mouse produce… (More)
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Highly Cited
1993
Highly Cited
1993
Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles.
1. 7-Nitro indazole (7-NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 +/- 0.1… (More)
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