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aspartimide

Known as: 2,5-Pyrrolidinedione, 3-amino- 
National Institutes of Health

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Broader (1)

Aspartic Acid
analogs & derivatives

Papers overview

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2010
2010
Aspartimide modified galanin analogue antagonizes galanin action on insulin secretion.
Aspartimide (Asi) formation is one of the most serious side reactions that can occur both during solid phase synthesis and… 
2010
2010
Synthesis of N-linked glycopeptides via solid-phase aspartylation.
An efficient strategy for the preparation of N-linked glycopeptides is described. The method relies on the use of side chain… 
2009
2009
Design of protecting groups for the beta-carboxylic group of aspartic acid that minimize base-catalyzed aspartimide formation.
With the objectives of developing new protecting groups for the beta-carboxyl group of aspartic acid that are resistant to base… 
2008
2008
Problem of aspartimide formation in Fmoc‐based solid‐phase peptide synthesis using Dmab group to protect side chain of aspartic acid
The sequence‐dependent, acid‐ or base‐catalysed aspartimide formation is one of the most serious side reactions in solid‐phase… 
2008
2008
Synthesis and Characterization of a POSS-Maleimide Precursor for Hybrid Nanocomposites
Epoxy polyhedral oligomeric silsesquioxane (POSS)-based hybrid nanocomposites were prepared by in situ polymerization of a… 
2005
2005
α‐ and β‐ aspartyl peptide ester formation via aspartimide ring opening
The undesirable reaction of aspartimide formation has been proved to occur under both acid and base conditions in solid‐phase… 
2003
2003
Synthesis of peptide sequences related to thrombospondin: factors affecting aspartimide by-product formation.
Aspartimide formation is one of the most common secondary reactions on solid phase peptide synthesis. In the present work, we… 
Highly Cited
2000
Highly Cited
2000
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
Established methodology for the preparation of peptide thioesters requires the use of t‐butoxycarbonyl chemistry owing to the… 
1996
1996
Solid-phase synthesis of tailed cyclic peptides: The use of α-allyl-protected aspartic acid leads to aspartimide and tetramethylguanidinium formation
This paper discusses the application of a method developed for cyclic peptide synthesis using allyl-based sidechain-protecting… 
Highly Cited
1988
Highly Cited
1988
Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time.
Factors affecting aspartimide formation, such as protecting groups, acidity, basicity, and temperature, were studied using the… 
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