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aspartimide

Known as: 2,5-Pyrrolidinedione, 3-amino- 
National Institutes of Health

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Broader (1)

Aspartic Acid
analogs & derivatives

Papers overview

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Highly Cited
2015
Highly Cited
2015
Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain**
Peptide ligases expand the repertoire of genetically encoded protein architectures by synthesizing new peptide bonds… 
Highly Cited
2012
Highly Cited
2012
Convergent solid-phase synthesis of N-glycopeptides facilitated by pseudoprolines at consensus-sequence Ser/Thr residues.
Highly Cited
2012
Highly Cited
2012
Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis.
Aspartimide formation is one of the major obstacles that impedes the solid phase synthesis of large peptides and proteins. Until… 
2008
2008
Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold
An efficient, all-solid-phase synthesis of argifin, a cyclic peptide chitinase inhibitor with chemotherapeutic potential, is… 
Highly Cited
2007
Highly Cited
2007
Limiting racemization and aspartimide formation in microwave‐enhanced Fmoc solid phase peptide synthesis
Microwave energy represents an efficient manner to accelerate both the deprotection and coupling reactions in 9… 
Highly Cited
2003
Highly Cited
2003
The aspartimide problem in Fmoc‐based SPPS. Part I
A variety of Asp β‐carboxy protecting groups, Hmb backbone protection and a range of Fmoc cleavage protocols have been employed… 
Highly Cited
2003
Highly Cited
2003
The aspartimide problem in Fmoc‐based SPPS. Part II
The sequence dependence of base‐catalysed aspartimide formation during Fmoc‐based SPPS was systematically studied employing the… 
Highly Cited
2000
Highly Cited
2000
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation
Established methodology for the preparation of peptide thioesters requires the use of t‐butoxycarbonyl chemistry owing to the… 
Highly Cited
1995
Highly Cited
1995
Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis
We have examined the sequence dependence of aspartimide formation during Fmoc-based solid-phase synthesis of the peptide Val-Lys… 
Highly Cited
1988
Highly Cited
1988
Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time.
Factors affecting aspartimide formation, such as protecting groups, acidity, basicity, and temperature, were studied using the… 
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