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aspartimide

Known as: 2,5-Pyrrolidinedione, 3-amino- 
National Institutes of Health

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Broader (1)

Aspartic Acid
analogs & derivatives

Papers overview

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2010
2010
Aspartimide modified galanin analogue antagonizes galanin action on insulin secretion.
Aspartimide (Asi) formation is one of the most serious side reactions that can occur both during solid phase synthesis and… 
2009
2009
Design of protecting groups for the beta-carboxylic group of aspartic acid that minimize base-catalyzed aspartimide formation.
With the objectives of developing new protecting groups for the beta-carboxyl group of aspartic acid that are resistant to base… 
2009
2009
Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide…
The Arg-Gly-Asp (RGD) sequence is the key recognition site in many adhesive interactions. To probe the structural and… 
2007
2007
1,4‐Diazepine‐2,5‐dione ring formation during solid phase synthesis of peptides containing aspartic acid β‐benzyl ester
The Fmoc‐based SPPS of H‐Xaa‐Asp(OBzl)‐Yaa‐Gly‐NH2 sequences results in side reactions yielding not only aspartimide peptides and… 
2003
2003
Synthesis of peptide sequences related to thrombospondin: factors affecting aspartimide by-product formation.
Aspartimide formation is one of the most common secondary reactions on solid phase peptide synthesis. In the present work, we… 
1999
1999
Linear analogues derived from the first EGF‐like domain of human blood coagulation factor VII: enhanced inhibition of FVIIa/TF complex activity by backbone modification through aspartimide formation
Coagulation factor VII bound to its cofactor tissue factor is the physiological initiator of blood coagulation. The interaction… 
1996
1996
Solid-phase synthesis of tailed cyclic peptides: The use of α-allyl-protected aspartic acid leads to aspartimide and tetramethylguanidinium formation
This paper discusses the application of a method developed for cyclic peptide synthesis using allyl-based sidechain-protecting… 
1991
1991
Synthesis and evaluation of constrained peptide analogues related to the N-terminal region of human growth hormone.
The synthesis and incorporation of two different isomeric gamma-lactam structures into peptide analogues related to hGH [6-13… 
1989
1989
Amino acids and peptides. XXV. Application of newly developed beta-1- and beta-2-adamantylaspartates to peptide synthesis by solid phase and conventional solution methods.
Newly developed beta-1- and beta-2-adamantylaspartates [H-Asp(O-1-Ada)-OH and H-Asp(O-2-Ada)-OH] were applied to the synthesis of… 
Highly Cited
1988
Highly Cited
1988
Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time.
Factors affecting aspartimide formation, such as protecting groups, acidity, basicity, and temperature, were studied using the… 
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