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Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.
  • J. Tam
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 1988
The multiple antigen peptide system provided a general, but chemically unambiguous, approach for the preparation of carrier-bound antigens of predetermined and reproducible structure and might be suitable for generating vaccines. Expand
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.
The results show that the macrocyclic peptides possess specific and potent antimicrobial activity that is salt-dependent and that their initial interactions with the microbial surfaces may be electrostatic, an effect commonly found in defensin antimicrobial peptides. Expand
Human Coronaviruses: A Review of Virus–Host Interactions
Various cellular processes, such as apoptosis, innate immunity, ER stress response, mitogen-activated protein kinase (MAPK) pathway and nuclear factor kappa B (NF-κB) pathway that may be modulated by HCoVs are discussed. Expand
Antimicrobial Peptides from Plants
The ability of plant AMPs to tolerate hypervariable sequences using a conserved scaffold provides diversity to recognize different targets by varying the sequence of the non-cysteine residues, which bode well for developing plant AMP as potential therapeutics and for protection of crops through transgenic methods. Expand
Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain a and Cyclotide Domains in the Fabaceae Family*
It is shown unambiguously that the cliotides are cyclotides and not A1bs, as determined by their sequence homology, disulfide connectivity, and membrane active properties indicated by their antimicrobial activities against Escherichia coli and cytotoxicities to HeLa cells. Expand
Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis.
Proteases are ubiquitous in nature, whereas naturally occurring peptide ligases, enzymes catalyzing the reverse reactions of proteases, are rare occurrences. Here we describe the discovery ofExpand
Lipid rafts are involved in SARS-CoV entry into Vero E6 cells
It is reported that lipid rafts in Vero E6 cells are involved in the entry of severe acute respiratory syndrome coronavirus (SARS-CoV). Expand
Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope.
The gene encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium vivax has been cloned and a synthetic 18-amino acid peptide binds to a monoclonal antibody directed to the CS protein and inhibits the interaction of this antibody with the native protein in sporozoite extracts. Expand
Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.
A rapid and sensitive method for the quantitative determination of free amino groups during solid-phase peptide synthesis has been developed and is useful for measuring the total number of peptide chains on the resin and, especially, for monitoring the progress of the coupling reaction. Expand
Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance.
Broad expression of TGF alpha in human breast cancer, its hormonal regulation in an estrogen-responsive cell line, and its possible functional significance in MCF-7 cell growth are demonstrated. Expand