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arcaine

Known as: 1,4-diguanidinobutane, tetramethylenediguanide 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of… Expand
Highly Cited
2006
Highly Cited
2006
Agmatine is a polyamine and has been considered as a novel neurotransmitter or neuromodulator in the central nervous system. In… Expand
Highly Cited
2004
Highly Cited
2004
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA… Expand
Highly Cited
1999
Highly Cited
1999
  • X. C. Yang, D. Reis
  • The Journal of pharmacology and experimental…
  • 1999
  • Corpus ID: 804270
We investigated in rat hippocampus neurons whether 4-(aminobutyl)guanidine (agmatine), formed by decarboxylation of L-arginine by… Expand
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1999
1999
Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors… Expand
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Highly Cited
1998
Highly Cited
1998
It has been suggested that the anticraving drug, acamprosate, acts via the glutamatergic system, but the exact mechanism of… Expand
1992
1992
Arcaine, a putative competitive antagonist at the polyamine site on the N-methyl-D-aspartate (NMDA) receptor complex, not only… Expand
Highly Cited
1990
Highly Cited
1990
  • I. Reynolds
  • The Journal of pharmacology and experimental…
  • 1990
  • Corpus ID: 19391897
This study investigated the interaction between the polyamines spermine and spermidine and the N-methyl-D-aspartate (NMDA… Expand
Highly Cited
1990
Highly Cited
1990
  • I. Reynolds
  • European journal of pharmacology
  • 1990
  • Corpus ID: 4550872
In this report I describe the actions of arcaine, a novel antagonist of the NMDA receptor that appears to act as a competitive… Expand
Highly Cited
1965
Highly Cited
1965
Summary The volume of normal human platelets, measured with a Coulter Counter, was approximately 5.8 μ3 when the platelets were… Expand
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