arcaine

Known as: 1,4-diguanidinobutane, tetramethylenediguanide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
051019532017

Papers overview

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2011
2011
Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state… (More)
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2008
2008
The polyamines putrescine, spermidine, and spermine are a group of aliphatic amines that may act as physiological modulators of… (More)
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Highly Cited
2004
Highly Cited
2004
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA… (More)
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2002
2002
Ifenprodil, arcaine and agmatine have all been reported to inhibit the NMDA receptor by actions at polyamine-sites, however the… (More)
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1999
1999
Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors… (More)
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1999
1999
The NMDA receptor complex is thought to be altered in kindling, an animal model for complex partial epilepsy. This receptor… (More)
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Highly Cited
1999
Highly Cited
1999
We investigated in rat hippocampus neurons whether 4-(aminobutyl)guanidine (agmatine), formed by decarboxylation of L-arginine by… (More)
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Highly Cited
1998
Highly Cited
1998
It has been suggested that the anticraving drug, acamprosate, acts via the glutamatergic system, but the exact mechanism of… (More)
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1992
1992
Arcaine, a putative competitive antagonist at the polyamine site on the N-methyl-D-aspartate (NMDA) receptor complex, not only… (More)
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1990
1990
  • I. Reynolds
  • The Journal of pharmacology and experimental…
  • 1990
This study investigated the interaction between the polyamines spermine and spermidine and the N-methyl-D-aspartate (NMDA… (More)
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