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N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium.
TLDR
The present findings show that treatment with NAC prevented the Cd-mediated decrease in AChE activity, as well as oxidative stress and consequent memory impairment in C d-exposed rats, demonstrating that this compound may modulate cholinergic neurotransmission and consequently improve cognition. Expand
Polyamines reduces lipid peroxidation induced by different pro-oxidant agents
TLDR
The present findings suggest that the observed effects of polyamines are not related to the activation of NMDA receptor but with their antioxidant and free radical scavenger properties. Expand
Intra-Amygdala Administration of Polyamines Modulates Fear Conditioning in Rats
TLDR
Evidence is provided that endogenous and exogenous polyamines modulate the acquisition or early consolidation of the fear-conditioning task in the amygdala, as well as reversing the facilitatory effect of spermidine. Expand
Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats.
TLDR
It is shown that treatment with resveratrol prevents the increase in AChE activity and consequently memory impairment in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and consequently improve cognition. Expand
Spermine reverses lipopolysaccharide-induced memory deficit in mice
TLDR
Spermine protects against LPS-induced memory deficits in mice by a mechanism that involves GluN2B receptors, and reversed the cognitive impairment induced by LPS. Expand
Antioxidant Properties of New Chalcogenides Against Lipid Peroxidation in Rat Brain
TLDR
(AA-Se)2 and (AA-S)2 can be considered as potential pharmaceutical antioxidant agents, respectively, after thiobarbituric reactive species (TBARS) production by rat brain homogenates was determined colorimetrically. Expand
Intrahippocampal spermidine administration improves inhibitory avoidance performance in rats
TLDR
Evidence that polyamines may be involved in learning and memory modulation is provided by the results of this investigation of the effect of an intrahippocampal infusion of spermidine immediately post‐training on the inhibitory avoidance learning paradigm in rats. Expand
Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.
TLDR
Evidence is provided that polyamines may be involved in learning and memory modulation in the amygdala and co-administration of arcaine and spermidine completely reversed the sperMidine-induced increase of test step-down latencies. Expand
Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes.
TLDR
An association between the long-term diet of potato tuber and a clear anxiolytic effect is suggested between Cd-intoxicated rats and a marked increase of brain Cd concentration, and increase and decrease of AChE and Na+,K+-ATPase activities, respectively. Expand
Time-dependent modulation of inhibitory avoidance memory by spermidine in rats
TLDR
Evidence is provided that the modulatory effects of spermidine on the acquisition and/or early consolidation of memory of inhibitory avoidance tasks in the hippocampus occur within a limited time window. Expand
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