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Biguanides

Known as: Biguanide, Biguanides [Chemical/Ingredient] 
Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES… 
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (18)

1-(3-chlorophenyl)biguanide2,4-dimethoxyphenyl biguanide2-tolylbiguanide3,4-dichlorophenylbiguanide
24 HR Metformin hydrochloride 500 MG Extended Release Oral TabletBiguanide [EPC]In BloodMetformin

Broader (1)

Hypoglycemic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues… 
Highly Cited
2014
Highly Cited
2014
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… 
Highly Cited
2013
Highly Cited
2013
Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
Highly Cited
2012
Highly Cited
2012
Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP
Glucose production by the liver is essential for providing a substrate for the brain during fasting. The inability of insulin to… 
Review
2012
Review
2012
Cellular and molecular mechanisms of metformin: an overview.
Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of… 
Highly Cited
2010
Highly Cited
2010
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Highly Cited
2010
Highly Cited
2010
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer… 
Review
2008
Review
2008
The Barrier of Hypoglycemia in Diabetes
Glycemic control, a worthwhile goal for people with diabetes, is limited by the barrier of iatrogenic hypoglycemia (1… 
Highly Cited
2003
Highly Cited
2003
Genetic cause of hyperglycaemia and response to treatment in diabetes
Review
1992
Review
1992
Biguanides and NIDDM
  • C. Bailey
  • Diabetes Care
  • 1992
  • Corpus ID: 35057771
The main biguanides, metformin and phenformin, were introduced in 1957 as oral glucose-lowering agents to treat non-insulin… 
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