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Biguanides

Known as: Biguanide, Biguanides [Chemical/Ingredient] 
Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues… Expand
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Highly Cited
2014
Highly Cited
2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… Expand
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Highly Cited
2013
Highly Cited
2013
Glucose production by the liver is essential for providing a substrate for the brain during fasting. The inability of insulin to… Expand
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Review
2012
Review
2012
Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of… Expand
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Highly Cited
2010
Highly Cited
2010
Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer… Expand
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Review
2010
Review
2010
  • M. Pollak
  • Cancer Prevention Research
  • 2010
  • Corpus ID: 1168791
Retrospective studies that may be impractical to confirm prospectively suggest that diabetics treated with metformin have a… Expand
Highly Cited
2009
Highly Cited
2009
This report presents an algorithm to assist primary care physicians, endocrinologists, and others in the management of adult… Expand
Review
2008
Review
2008
Glycemic control, a worthwhile goal for people with diabetes, is limited by the barrier of iatrogenic hypoglycemia (1… Expand
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Review
2002
Review
2002
Insulin resistance contributes greatly to development of cardiovascular disease in patients with the metabolic syndrome and its… Expand
Review
1992
Review
1992
  • C. Bailey
  • Diabetes Care
  • 1992
  • Corpus ID: 35057771
The main biguanides, metformin and phenformin, were introduced in 1957 as oral glucose-lowering agents to treat non-insulin… Expand
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