Skip to search formSkip to main contentSkip to account menu

Metformin

Known as: Metformine, Dimethylbiguanid, Imidodicarbonimidic diamide, N,N-dimethyl- 
An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Metformin is associated with a very low incidence of… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of… 
Review
2011
Review
2011
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine… 
Highly Cited
2006
Highly Cited
2006
BACKGROUND The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term… 
Highly Cited
2005
Highly Cited
2005
Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase… 
Highly Cited
2005
Highly Cited
2005
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma… 
Highly Cited
2001
Highly Cited
2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose… 
Highly Cited
2000
Highly Cited
2000
Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here… 
Highly Cited
1995
Highly Cited
1995
BACKGROUND Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus…