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Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of… Expand Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine… Expand BACKGROUND
The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term… Expand Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase… Expand The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK… Expand BACKGROUND
Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma… Expand Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose… Expand BACKGROUND
In patients with type 2 diabetes, intensive blood-glucose control with insulin or sulphonylurea therapy decreases… Expand BACKGROUND
Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus… Expand BACKGROUND
The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has… Expand