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Metformin

Known as: Metformine, Dimethylbiguanid, Imidodicarbonimidic diamide, N,N-dimethyl- 
An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Metformin is associated with a very low incidence of… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of… Expand
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Review
2011
Review
2011
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term… Expand
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Highly Cited
2005
Highly Cited
2005
Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase… Expand
Highly Cited
2005
Highly Cited
2005
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK… Expand
Highly Cited
2002
Highly Cited
2002
BACKGROUND Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma… Expand
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Highly Cited
2001
Highly Cited
2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND In patients with type 2 diabetes, intensive blood-glucose control with insulin or sulphonylurea therapy decreases… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has… Expand