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Metformin

Known as: Metformine, Dimethylbiguanid, Imidodicarbonimidic diamide, N,N-dimethyl- 
An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Metformin is associated with a very low incidence of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights… Expand
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Review
2011
Review
2011
BACKGROUND Latent autoimmune diabetes in adults (LADA) is a slowly developing type 1 diabetes. OBJECTIVES To compare… Expand
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The antidiabetic properties of metformin are mediated through its ability to activate the AMP-activated protein kinase… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term… Expand
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Highly Cited
2005
Highly Cited
2005
Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase… Expand
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Highly Cited
2005
Highly Cited
2005
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma… Expand
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Highly Cited
2001
Highly Cited
2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND In patients with type 2 diabetes, intensive blood-glucose control with insulin or sulphonylurea therapy decreases… Expand
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