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Metformin

Known as: Metformine, Dimethylbiguanid, Imidodicarbonimidic diamide, N,N-dimethyl- 
An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Metformin is associated with a very low incidence of… 
National Institutes of Health

Related topics

Related topics

41 relations
24 HR Metformin hydrochloride 1000 MG / saxagliptin 2.5 MG Extended Release Oral Tablet [Kombiglyze]24 HR Metformin hydrochloride 1000 MG / sitagliptin 50 MG Extended Release Oral Tablet [Janumet]24 HR Metformin hydrochloride 500 MG Extended Release Oral TabletBiguanides

Narrower (11)

AvandametCidophageGlucinanGlucovance

Broader (1)

Hypoglycemic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis
Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory… 
Highly Cited
2013
Highly Cited
2013
Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to… 
Review
2012
Review
2012
Metformin pathways: pharmacokinetics and pharmacodynamics
Departments of Genetics, Bioengineering, Stanford University Medical Center, Stanford University, Stanford and Department of… 
Review
2012
Review
2012
Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis.
OBJECTIVE Oral antidiabetic drugs (including metformin and sulfonylurea) may play a role in the relationship between type 2… 
Highly Cited
2011
Highly Cited
2011
Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
Metformin is the most widely used antidiabetic drug because of its proven efficacy and limited secondary effects. Interestingly… 
Highly Cited
2011
Highly Cited
2011
Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
Purpose: Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated… 
Highly Cited
2009
Highly Cited
2009
The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
Organic cation transporters (OCTs) can mediate metformin transmembrane transport. We explored metformin pharmacokinetics in… 
Highly Cited
2008
Highly Cited
2008
Metformin slows down aging and extends life span of female SHR mice
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in… 
Highly Cited
2004
Highly Cited
2004
AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells*
The antidiabetic drug metformin stimulates AMP-activated protein kinase (AMPK) activity in the liver and in skeletal muscle. To… 
Review
1996
Review
1996
Clinical Pharmacokinetics of Metformin
SummaryThe biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non… 
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