Metformin slows down aging and extends life span of female SHR mice.

  title={Metformin slows down aging and extends life span of female SHR mice.},
  author={Vladimir N. Anisimov and Lev M Berstein and Peter A. Egormin and Tatiana S. Piskunova and Irina G. Popovich and Mark A. Zabezhinski and Margarita L. Tyndyk and Maria V. Yurova and I. G. Kovalenko and Tatiana E. Poroshina and Anna V. Semenchenko},
  journal={Cell cycle},
  volume={7 17},
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which resemble effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity. Antidiabetic… CONTINUE READING
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