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Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain
TLDR
It is concluded that induction of DKK1 contributes to the pathological cascade triggered by β-amyloid and is critically involved in the process of tau phosphorylation. Expand
Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials
TLDR
Omega-3 PUFA resulted effective in RCTs on patients with bipolar disorder, whereas no evidence was found for those exploring their efficacy on depressive symptoms in young populations, perinatal depression, primary disease other than depression and healthy subjects. Expand
Methionine synthase (MTR) 2756 (A → G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors
TLDR
Results provide evidences that homocysteine and MTR genetic polymorphism are two potent risk factors for mothers to have a DS child in Sicily. Expand
β-Amyloid Monomers Are Neuroprotective
TLDR
Synthetic Aβ1-42 monomers support the survival of developing neurons under conditions of trophic deprivation and protect mature neurons against excitotoxic death, a process that contributes to the overall neurodegeneration associated with AD. Expand
Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms
TLDR
Tertiary prevention with omega-3 PUFA supplement in depressed patients has reached greater effectiveness during the last recent years, although definitive statements on their use in depression therapy cannot be yet freely asserted. Expand
TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.
TLDR
It is found that a 24-h treatment with TGF-beta1 induced alpha-smooth actin (SMA) expression and collagen production in human lung fibroblasts via ERK1/2 activation, GSK-3beta inhibition and nuclear beta-catenin translocation. Expand
Depression and Alzheimer's disease: neurobiological links and common pharmacological targets.
TLDR
The evidence on the common molecular pathways between depression and Alzheimer's disease is examined and these pathways are discussed as new pharmacological targets for the treatment of both major depression and Alzheimers disease. Expand
Clinically Significant Drug Interactions with Newer Antidepressants
TLDR
Although drug interactions with newer antidepressants are potentially, but rarely, clinically significant, the use of antidepressants with a more favourable drug interaction profile is advisable. Expand
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
TLDR
The demonstration that DKK1 inhibits Wnt signaling in neurons and causes neuronal death supports the hypothesis that inhibition of the canonical Wnt pathway contributes to the pathophysiology of neurodegenerative disorders. Expand
Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease
TLDR
In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE &egr;4 alleles. Expand
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