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aprosulate

Known as: D-Gluconamide, N,N'-1,3-propanediylbis(4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl))-, 2,2',3,3',5,5',6,6'-octakis(hydrogen sulfate), hexadecasodium salt, N,N'-Trimethylenebis(Actobionamide) Hexadecakis Sulfate (Ester) 
A synthetic sulfated bis(lactobionic acid amide) derivative and heparin analogue with anticoagulant activity. Aprosulate is made up of two fully… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

AnticoagulantsDisaccharidesFibrinolytic AgentsPolysaccharides
Aprosulate Sodium

Narrower (1)

LW 10082

Papers overview

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2020
2020
Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment
Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth… 
2001
2001
Ecarin Clotting Time is Sensitive to Heparinoids: Comparison of Two Different Techniques
Ecarin clotting time (ECT) is currently developed for the specific monitoring of antithrombin drugs, such as hirudin, argatroban… 
1999
1999
Effects of Aprosulate, a Novel Synthetic Glycosaminoglycan, on Coagulation and Platelet Function Parameters: A Prospective, Randomized Phase I Study
In a phase I clinical trial the effect of the highly sulfated polyanion "Aprosulate" was studied in healthy volun teers using… 
1996
1996
Physical and pharmacologic manipulation of the vascular system as measured by the release of TFPI and other mediators of antithrombotic actions.
Utilizing highly sensitive monoclonal based assays, we have measured various mediators of antithrombotic action including t-PA… 
1996
1996
Occlusive thrombosis in the femoral artery of the rabbit: a pharmacological model for evaluating antiplatelet and anticoagulant agents
Arterial thrombosis in the rabbit was established as a novel model to evaluate the effects of antithrombotic agents. Endothelial… 
1995
1995
Effect of repeated Aprosulate® and Enoxaparin® administration on tissue factor pathway inhibitor antigen levels
Tissue factor pathway inhibitor (TFPI) is a naturally occurring, Kunitz-type serine protease inhibitor whose anticoagulant… 
1994
1994
Protamine sulfate neutralization of the anticoagulant activity of Aprosulate, a synthetic sulfated lactobionic acid amide.
1993
1993
Phase I--study with aprosulate, a new synthetic anticoagulant.
1991
1991
Pharmacodynamics of a sulfated lactobionic acid amide-derived antithrombotic agent (Aprosulate) in primates.
1977
1977
A neutron diffraction refinement of N-(2-chloroethyl)-D-gluconamide
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