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Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
TLDR
The present results suggested that direct AMPA receptor activation may play an important role in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression, although other mechanisms might be involved in the sustained action. Expand
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood
TLDR
It is demonstrated that neonatal polyI:C treatment in DN-DISC1 mice resulted in the deficits of short-term, object recognition, and hippocampus-dependent fear memories after puberty, although polyI-C treatment by itself had smaller influences on wild-type mice, suggesting that combined effect of neonatalpolyI: C treatment and DN- DISC1 affects some behavioral and histological phenotypes in adulthood. Expand
Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist.
TLDR
It is demonstrated that RNH-6270 is a potent and AT1-selective angiotensin receptor antagonist and that, after oral administration, CS-866 has a long-lasting ang Elliotensin II inhibitory action which is not affected by drug metabolizing enzymes in the liver. Expand
Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats
TLDR
It is suggested that AMPA receptor stimulation at 24h after a single injection of ketamine or an mGlu2/3 receptor antagonist is required to produce the anti-immobility effects of these compounds. Expand
Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus
TLDR
MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus, which is accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor. Expand
The in vivo pharmacological profile of CS‐747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
TLDR
In vivo pharmacological profiles of CS‐747 show that it is an orally active and a potent antiplatelet and antithrombotic agent with a rapid onset and long duration of action, and warrants clinical evaluations of the agent. Expand
Social isolation rearing‐induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion‐related behaviors in juvenile mice
TLDR
It is suggested that communication in juvenile is important in the survival and differentiation of newly divided cells, which may be associated with memory and aggression, and the possibility that the reduced expression of Nurr1 and/or Npas4 may contribute to the impairment of neurogenesis and memory and aggressive behaviour induced by SI is raised. Expand
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
TLDR
The present result suggests that the blockade of the mGlu2/3 receptor may activate mTOR signaling, and that the activation of m TOR signaling may contribute to the sustained antidepressant-like effects of mGLU2/ 3 receptor antagonists. Expand
Renoprotective effects of blockade of angiotensin II AT1 receptors in an animal model of type 2 diabetes.
TLDR
Results indicate that AT1 receptor blockade with olmesartan retards the progression of nephropathy associated with type 2 diabetes without affecting glucose metabolism, and that this renal protective effect is at least partly independent of the antihypertensive effect of the drug. Expand
Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in
TLDR
It is concluded that pravastatin exhibits a liver-selective inhibition of sterol synthesis because the agent permeates the cell membrane in the liver, but not in non-hepatic tissues. Expand
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