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apoptotic signaling pathway

Known as: apoptotic signalling pathway, induction of apoptosis by extracellular signals 
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Apoptosis

Narrower (3)

apoptosome assemblymitochondrial outer membrane permeabilizationrelease of cytochrome c from mitochondria

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL.
MicroRNA-21 (miR-21) has been found to be upregulated in keloid tissue and to affect the proliferation and apoptosis of keloid… 
2013
2013
p14ARF inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway
Epidermal growth factor receptor (EGFR) stimulates proliferative and survival signals. Activating mutations of EGFR are involved… 
2008
2008
Death receptor-4 (DR4) expression is regulated by transcription factor NF-κB in response to etoposide treatment
Tumour necrosis factor related apoptosis inducing ligand (TRAIL) binds to death receptor 4 (DR4) activating the apoptotic… 
2007
2007
Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53
The urokinase-type plasminogen activator receptor (uPAR) is involved in several biological processes, including proteolysis… 
Review
2004
Review
2004
Tissue specificity of apoptotic signal transduction
Two major apoptotic pathways exist in mammalian cells: the death receptor and mitochondrial pathways. The cross talk between… 
Review
2004
Review
2004
Regulation of apoptotic signal transduction pathways by the heat shock proteins
The study about apoptotic signal transductions has become a project to reveal the molecular mechanisms of apoptosis. Heat shock… 
2004
2004
GENDER DIFFERENCES IN MYOCARDIAL APOPTOTIC SIGNALING AND RECOVERY FOLLOWING ACUTE INJURY.: 67
2001
2001
Regulation of the Retinoblastoma-Dependent Mdm2 and E2F-1 Signaling Pathways during Neuronal Apoptosis
We have previously demonstrated that the apoptotic signaling pathway in K(+)-deprived cerebellar granule neurons involves a… 
1999
1999
Rac-dependent Anti-apoptotic Signaling by the Insulin Receptor Cytoplasmic Domain*
Mutations in the cytoplasmic domain of the insulin receptor that block the ability of the receptor to stimulate glucose uptake do… 
Review
1998
Review
1998
Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?
p21-activated kinase 2 (PAK2) is proteolytically cleaved during apoptosis through the action of DEVD-sensitive caspase(s). This… 
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