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Genomic alterations in cultured human embryonic stem cells
TLDR
The observation that hESC lines maintained in vitro develop genetic and epigenetic alterations implies that periodic monitoring of these lines will be required before they are used in in vivo applications and that some late-passage hESS lines may be unusable for therapeutic purposes.
Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
TLDR
This study demonstrates that expression of G2019S mutant LRRK2 induces the degeneration of nigrostriatal pathway dopaminergic neurons in an age-dependent manner, and will provide important tools for understanding the mechanism(s) through which familial mutations precipitate neuronal degeneration and PD.
Prevalence of psoriasis in China: a population-based study in six cities.
TLDR
This population-based and dermatologist-confirmed study showed that the prevalence of psoriasis in China is 0.47%, which is higher than that reported in 1987.
Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
TLDR
It is concluded that FAM20C may regulate osteogenesis through its direct role in facilitating osteoblast differentiation and its systemic regulation of phosphate homeostasis via the mediation of FGF23.
Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease
TLDR
The results show that a transgenic mouse model of Aβ pathology develops progressive MAergic neurodegeneration occurring in AD cases, and it is shown that the progression forebrain Aβ deposition in the APPswe/PS1ΔE9 model is associated with progressive losses of the forebrain MAergic afferents.
The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis.
TLDR
Downregulation of miR-26a in the lungs of mice with experimental pulmonary fibrosis and in IPF, which resulted in posttranscriptional derepression of connective tissue growth factor (CTGF), and induced collagen production, is found.
Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy
TLDR
Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls, and miR-106b-5p had the best diagnostic value for epilepsy with 80.3% sensitivity and 81.2% specificity.
Linking spectral and electrochemical analysis to monitor c-type cytochrome redox status in living Geobacter sulfurreducens biofilms.
TLDR
The goal of this work was to design a system able to support growth of metal-reducing bacteria on transparent conductive electrodes to link potential-dependent changes with real-time measurements of spectral signatures in an undamaged biofilm network.
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