release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic… (More)
National Institutes of Health

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apoptotic signaling pathway

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2006
2006
Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition.
The mitochondrial Ca(2+)-independent phospholipase A(2) is activated during energy-dependent Ca(2+) accumulation under conditions… (More)
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Highly Cited
2005
Highly Cited
2005
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.
Aberrant overexpression of antiapoptotic members of the Bcl-2 protein family, including Bcl-2 and Bcl-X(L), contributes to… (More)
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2004
2004
Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/caspase pathway, associated with degradation of beta-catenin, pRb and Bcl-XL.
Butyrate can promote programmed cell death in a number of tumour cells in vitro. This paper provides evidence that butyrate… (More)
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Highly Cited
2002
Highly Cited
2002
The role of cytochrome c in caspase activation in Drosophila melanogaster cells
The release of cytochrome c from mitochondria is necessary for the formation of the Apaf-1 apoptosome and subsequent activation… (More)
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2002
2002
Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c.
We have shown previously that depletion of polyamines delays apoptosis induced by camptothecin in rat intestinal epithelial cells… (More)
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2001
2001
Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia.
It has previously been shown that apoptosis is increased in ischaemic/reperfused heart. However, little is known about the… (More)
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Highly Cited
1999
Highly Cited
1999
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes.
Nitric oxide (NO) is a potent inhibitor of apoptosis in many cell types, including hepatocytes. We and others have described NO… (More)
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Highly Cited
1998
Highly Cited
1998
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.
Apoptosis often involves the release of cytochrome c from mitochondria, leading to caspase activation. However, in apoptosis… (More)
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Highly Cited
1998
Highly Cited
1998
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
The major heat shock protein, Hsp70, is an effective inhibitor of apoptosis. To study its mechanism of action, we created tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis
Apoptosis is induced by different stimuli, among them triggering of the death receptor CD95, staurosporine, and chemotherapeutic… (More)
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