FAQ

antibiotic biosynthetic process

Known as: antibiotic formation, antibiotic biosynthesis, antibiotic synthesis 
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
051019462016

Papers overview

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2013
2013
Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.
The two-component system AfsQ1/Q2 of Streptomyces coelicolor was identified in our previous work as a pleiotropic regulator for… (More)
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2010
2010
"Pseudo" gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotic biosynthesis.
In actinomycetes, the onset of secondary metabolite biosynthesis is often triggered by the quorum-sensing signal gamma… (More)
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2008
2008
afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor
Two-component system AfsQ1-Q2 of Streptomyces coelicolor was identified previously for its ability to stimulate actinorhodin (ACT… (More)
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2007
2007
How do antibiotic-producing bacteria ensure their self-resistance before antibiotic biosynthesis incapacitates them?
Acquired antibiotic resistance among dangerous bacterial pathogens is an increasing medical problem. While in Mycobacterium… (More)
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2002
2002
Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans.
We found that the biosynthesis of actinorhodin (Act), undecylprodigiosin (Red), and calcium-dependent antibiotic (CDA) are… (More)
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Highly Cited
2001
Highly Cited
2001
Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase.
In Streptomyces, a family of related butyrolactones and their corresponding receptor proteins serve as quorum-sensing systems… (More)
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1990
1990
Mutations in a new Streptomyces coelicolor locus which globally block antibiotic biosynthesis but not sporulation.
Streptomyces coelicolor produces four known antibiotics. To define genetic elements that regulate antibiotic synthesis, we… (More)
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1989
1989
Use of Recombinant DNA to Improve Production of Cephalosporin C By Cephalosporium acremonium
A recombinant DNA-modified strain of the filamentous fungus Cephalosporium acremonium, strain LU4-79-6, produced more of the… (More)
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1989
1989
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
Key information about the biosynthesis of polyketide metabolites has been uncovered by sequence analysis of the tetracenomycin C… (More)
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Highly Cited
1984
Highly Cited
1984
Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host.
The application of molecular cloning to antibiotic-producing microorganisms should lead to enhanced antibiotic productivity and… (More)
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