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Production of recombinant proteins by microbes and higher organisms.
Cellulase, Clostridia, and Ethanol
The need for such a process, the cellulases of clostridia, their presence in extracellular complexes or organelles (the cellulosomes), the binding of the cellulosome to cellulose and to the cell surface, cellulase genetics, regulation of their synthesis, cocultures, ethanol tolerance, and metabolic pathway engineering for maximizing ethanol yield are discussed.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
It is reported that triptolide covalently binds to human XPB, a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription and likely nucleotide excision repair.
Manual of Industrial Microbiology and Biotechnology
The aim of this treatise is to establish a baseline for the design and application of forgiveable errors in the treatment of infectious disease.
Pharmaceutically active secondary metabolites of microorganisms
- A. Demain
- BiologyApplied Microbiology and Biotechnology
- 1 October 1999
The recently increased development of resistance to older antibacterial and antifungal drugs is being met with the use or clinical testing of older, underutilized or previously nondeveloped narrow-spectrum antibacterial products as well as powerful semisynthetic antIFungal agents.
Microbial drug discovery: 80 years of progress
This review centers on these beneficial secondary metabolites, the discovery of which goes back 80 years to the time when penicillin was discovered by Alexander Fleming.
The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions.
The present study focuses on the development of anti-inflammatory drugs in the context of the industrial revolution and the role of pharmaceuticals in this process.
Effect of nutrition of Monascus sp. on formation of red pigments
A new chemically defined medium was devised containing 5% maltose, 75 mm MSG, phosphate and MgSO4 at lower concentrations plus other mineral salts, which yielded a tenfold increase in OD500 and a reversal of the pigment location from predominantly cell-bound, including both intracellular and surface-bound pigments, to mainly extracellular.
Metabolic regulation of fermentation processes