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Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria.
TLDR
Results indicate that Wag31 regulates cell shape and cell wall synthesis in M. tuberculosis through a molecular mechanism by which the activity of Wag31 can be modulated in response to environmental signals. Expand
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
TLDR
This unique feature of FK506 biosynthesis, in which a dedicated PKS provides an atypical extender unit for the main modular PKS, illuminates a new strategy for the combinatorial biosynthesis of designer macrolide scaffolds as well as FK505 analogues. Expand
Effects of actinobacteria on plant disease suppression and growth promotion
TLDR
This review summarizes the effects of actinobacteria as BCA, PGPA, and its beneficial associations with plants. Expand
Phylogenetic analysis of Streptomyces spp. isolated from potato scab lesions in Korea on the basis of 16S rRNA gene and 16S-23S rDNA internally transcribed spacer sequences.
TLDR
It was clarified that ITS regions are not useful in phylogenetic analysis of Streptomyces spp. Expand
Streptomyces xinghaiensis sp. nov., isolated from marine sediment.
TLDR
It is proposed that strain S187(T), isolated from a marine sediment sample collected from Xinghai Bay, Dalian, China, represents a novel species of the genus Streptomyces, for which the name StrePTomyces xinghaiensis sp. Expand
Accumulation of S-Adenosyl-l-Methionine Enhances Production of Actinorhodin but Inhibits Sporulation in Streptomyces lividans TK23
TLDR
The overexpression of the SAM-s gene in Streptomyces lividans TK23 inhibited sporulation and aerial mycelium formation but enhanced the production of actinorhodin in both agar plates and liquid media, concluding that the SAM plays important roles as an intracellular factor in both cellular differentiation and antibiotic production in StrePTomyces sp. Expand
Roles of fkbN in Positive Regulation and tcs7 in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP
TLDR
Semiquantitative reverse transcription-PCR analyses of the transcription levels of the FK506 biosynthetic genes in the wild-type and mutant strains proved that most of the fkbN encodes a positive regulatory protein essential for Fk506/FK520 biosynthesis and that the gene product of tcs7 negatively regulates their biosynthesis, demonstrating the potential of exploited for strain improvement. Expand
Hypertonic Stress Increased Extracellular ATP Levels and the Expression of Stress-Responsive Genes in Arabidopsis thaliana Seedlings
TLDR
Arabidopsis seedlings subjected to hypertonic stresses survived after incubation with β,γ-methyleneadenosine-5′-triphosphate, which usually causes cell death through competitive exclusion of ATP, and this confirms that the enhanced viability was due to accumulated exATP. Expand
Regulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria
TLDR
The phosphorylation state of Wag31 is found to be important for protein-protein interactions between the Wag31 molecules, and thus, for its polar localization, in polar peptidoglycan biosynthesis. Expand
Discovery and characterization of the tuberculosis drug lead ecumicin.
TLDR
Determination of absolute configuration and unambiguous structural confirmation were carried out by X-ray crystallography and Marfey's analysis and the resulting two possible planar structures were distinguished by LC-MS. Expand
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