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anti-B4 blocked ricin immunoconjugate

Known as: anti-B4 blocked ricin, monoclonal antibody, Anti B4-BR, Anti-B4-bR 
An immunotoxin comprised of an anti-B4 (anti-CD19) murine monoclonal antibody linked to the modified plant-derived toxin blocked ricin. The antibody… 
National Institutes of Health

Related topics

Related topics

9 relations
ApoptosisB-LymphocytesCD19 AntigensRibosomes

Broader (3)

ImmunoconjugatesMonoclonal AntibodiesRicin

Papers overview

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2002
2002
Identification of hypoglycemia in mice as a surrogate marker of ricin toxicosis.
PURPOSE In an effort to develop a non-lethal model of ricin toxicosis, we studied the biochemical effects of the administration… 
Highly Cited
1998
Highly Cited
1998
Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma.
Immunotoxins, composed of a monoclonal antibody conjugated to a protein toxin, mediate cell death through novel cytotoxic… 
Highly Cited
1995
Highly Cited
1995
Phase I Trial of an Anti‐CD19 Deglycosylated Ricin A Chain Immunotoxin in Non‐Hodgkin's Lymphoma: Effect of an Intensive Schedule of Administration
In a phase I trial, eight patients with non-Hodgkin's B-cell lym-phoma received mouse IgG1k monoclonal antibody HD37 specific for… 
1993
1993
Anti-B4-blocked ricin immunotoxin shows therapeutic efficacy in four different SCID mouse tumor models.
Anti-CD19 monoclonal antibody anti-B4 (IgG1) conjugated to the novel toxin-blocked ricin forms a potent immunotoxin, anti-B4… 
1993
1993
Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody.
1993
1993
Ricin enhances IgE responses by inhibiting a subpopulation of early-activated IgE regulatory CD8+ T cells.
Ricin, a toxic lectin from castor beans greatly enhances IgE responses to bee venom phospholipase A2 (PLA2) in high and low IgE… 
Highly Cited
1991
Highly Cited
1991
Immunotoxins constructed with anti‐CD25 monoclonal antibodies and deglycosylated ricin a‐chain have potent anti‐tumour effects against human hodgkin cells in vitro and solid hodgkin tumours in mice
Twenty‐three monoclonal antibodies (MAbs) against the IL‐2 receptor α‐chain (CD25) were evaluated as ricin A‐chain immunotoxins… 
1989
1989
The role of ricin B chain in the intracellular trafficking of anti-CD5 immunotoxins.
The mAb anti-CD5 was linked to purified ricin A chain (RTA) or intact ricin (Rc) containing B chain to determine the role of… 
Highly Cited
1989
Highly Cited
1989
The toxicity, distribution and excretion of ricin holotoxin in rats.
Highly Cited
1984
Highly Cited
1984
Blockade of the galactose-binding sites of ricin by its linkage to antibody. Specific cytotoxic effects of the conjugates.
A method is described for preparing specific cytotoxic agents by linking intact ricin to antibodies in a manner that produces… 
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