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anti-B4 blocked ricin immunoconjugate

Known as: anti-B4 blocked ricin, monoclonal antibody, Anti B4-BR, Anti-B4-bR 
An immunotoxin comprised of an anti-B4 (anti-CD19) murine monoclonal antibody linked to the modified plant-derived toxin blocked ricin. The antibody… Expand
National Institutes of Health

Related topics

Related topics

9 relations
ApoptosisB-LymphocytesCD19 AntigensRibosomes
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Broader (3)

ImmunoconjugatesMonoclonal AntibodiesRicin

Papers overview

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Highly Cited
2000
Highly Cited
2000
A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma.
This study used an 8-day continuous infusion regimen of a 1:1 mixture of two immunotoxins (ITs) prepared from deglycosylated… Expand
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Highly Cited
1998
Highly Cited
1998
Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma.
Immunotoxins, composed of a monoclonal antibody conjugated to a protein toxin, mediate cell death through novel cytotoxic… Expand
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Highly Cited
1997
Highly Cited
1997
Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin.
Anti-CD7-dgA, DA7, consists of deglycosylated ricin A chain coupled to a mouse monoclonal anti-human CD7 antibody. This study… Expand
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Highly Cited
1993
Highly Cited
1993
Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms.
PURPOSE This phase I trial was undertaken to determine the maximum-tolerated dose (MTD) and dose-limiting toxicities (DLTs) of… Expand
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Highly Cited
1993
Highly Cited
1993
Central oxytocin inhibition of salt appetite in rats: evidence for differential sensing of plasma sodium and osmolality.
Sodium chloride ingestion is stimulated during conditions of sodium deficiency to maintain body fluid and electrolyte balance… Expand
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Highly Cited
1992
Highly Cited
1992
Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion.
Anti-B4-blocked Ricin (Anti-B4-bR) is an immunotoxin comprised of the anti-B4 monoclonal antibody (MoAb) and the protein toxin… Expand
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Highly Cited
1988
Highly Cited
1988
Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.
A monoclonal anti-Thy-1.1 antibody (OX7) was coupled to either native or chemically deglycosylated ricin A-chain (dgA) using one… Expand
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Highly Cited
1988
Highly Cited
1988
Structures of sugar chains of ricin D.
The toxic lectin, ricin D, contains mannose, fucose, xylose, and N-acetylglucosamine as sugar components. Sugar chains are linked… Expand
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Highly Cited
1984
Highly Cited
1984
Blockade of the galactose-binding sites of ricin by its linkage to antibody. Specific cytotoxic effects of the conjugates.
A method is described for preparing specific cytotoxic agents by linking intact ricin to antibodies in a manner that produces… Expand
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Highly Cited
1980
Highly Cited
1980
Pathways involved in fluid phase and adsorptive endocytosis in neuroblastoma
The endocytosis of ricin, horseradish peroxidase (HRP), and a conjugate of ricin-HRP by monolayer cultures of murine… Expand
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