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alatrofloxacin

Known as: L-Alaninamide, L-alanyl-N-(3-(6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl)-3-azabicyclo(3.1.0)hex-6-yl)-, (1alpha,5alpha,6alpha)-, alatrofloxacin [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (2)

Alatrofloxacin mesylateCP 116,517

Broader (3)

Anti-Infective AgentsFluoroquinolonesTopoisomerase II Inhibitors
Bacteroides InfectionsBronchitisChlamydia InfectionsDecreased Protein Synthesis [PE]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections.
UNLABELLED Ceftriaxone is a parenteral third-generation cephalosporin with a long elimination half-life which permits once-daily… 
2002
2002
Comparison of Levofloxacin, Alatrofloxacin, and Vancomycin for Prophylaxis and Treatment of Experimental Foreign-Body-Associated Infection by Methicillin-Resistant Staphylococcus aureus
ABSTRACT The prophylactic and therapeutic activities of two fluoroquinolones, levofloxacin and alatrofloxacin (the l-Ala-l-Ala… 
Highly Cited
2001
Highly Cited
2001
In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones.
2000
2000
Severe Thrombocytopenia Associated with Alatrofloxacin
OBJECTIVE: To report the development of severe thrombocytopenia during alatrofloxacin therapy. CASE SUMMARY: A 54-year-old Native… 
1998
1998
Trovafloxacin in the treatment of intra-abdominal infections: results of a double-blind, multicenter comparison with imipenem/cilastatin. Trovafloxacin Surgical Group.
1998
1998
Safety and tolerability of intravenous-to-oral treatment and single-dose intravenous or oral prophylaxis with trovafloxacin.
1998
1998
Double-blind comparison of single-dose alatrofloxacin and cefotetan as prophylaxis of infection following elective colorectal surgery. Trovafloxacin Surgical Group.
BACKGROUND Alatrofloxacin, the prodrug of trovafloxacin, is a novel fluoroquinolone antimicrobial agent with a broad spectrum… 
Highly Cited
1997
Highly Cited
1997
Pharmacokinetics and safety of trovafloxacin in healthy male volunteers following administration of single intravenous doses of the prodrug, alatrofloxacin.
Fifteen healthy male volunteers (in four groups) received single 1 h i.v. infusions of alatrofloxacin (CP-116,517) equivalent to… 
1997
1997
Penetration of trovafloxacin into cerebrospinal fluid in humans following intravenous infusion of alatrofloxacin
A single-dose study was conducted to determine concentrations of trovafloxacin (CP-99,219) achieved in the cerebrospinal fluid… 
Highly Cited
1997
Highly Cited
1997
Oral bioavailability of trovafloxacin with and without food in healthy volunteers.
Two studies determined the oral bioavailability of trovafloxacin (CP-99,219) in healthy volunteers under fasted and fed… 
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