• Publications
  • Influence
Developmental pharmacology--drug disposition, action, and therapy in infants and children.
For those using drugs to treat infants and children, the integration of developmental pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity, distribution sites, andExpand
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Glucuronidation in Humans
During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but alsoExpand
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Handbook of basic pharmacokinetics-- including clinical applications
Handbook of basic pharmacokinetics-- including clinical applications , Handbook of basic pharmacokinetics-- including clinical applications , کتابخانه دیجیتال جندی شاپور اهواز
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The Pharmacokinetics and Safety of Micafungin, a Novel Echinocandin, in Premature Infants
Background: Candidal fungal infection rates in neonates are increasing and are a significant cause of mortality, especially in low birth weight infants. Micafungin is an echinocandin that works byExpand
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Cytochrome P450 3A
The maturation of organ systems during fetal life and childhood exerts a profound effect on drug disposition. The maturation of drug-metabolising enzymes is probably the predominant factor accountingExpand
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Impact of developmental pharmacology on pediatric study design: overcoming the challenges.
  • G. Kearns
  • Medicine
  • The Journal of allergy and clinical immunology
  • 1 September 2000
The need to establish drug-dosing guidelines in children highlights the challenges associated with the development of phases I and II pediatric clinical trials. These challenges are the consequenceExpand
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Clinical Pharmacokinetics in Infants and Children
SummaryA significant increase in the knowledge base in paediatric clinical pharmacology has occurred over the past 2 decades and has largely been the result of important scientific and sociologicalExpand
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Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N‐acetyltransferase‐2, and xanthine oxidase with the “Cooperstown cocktail”
Simultaneous administration of several probes enhances the utility of phenotyping, but poor specificity, side effects, and use of drugs not approved by the Food and Drug Administration limit theExpand
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The status of paediatric medicines initiatives around the world—what has happened and what has not?
PurposeThis review was conducted to examine the current status of paediatric medicines initiatives across the globe.MethodsThe authors made a non-systematic descriptive review of current worldExpand
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Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Cytochrome P-450 (CYP) 2D6 is responsible for the biotransformation of over 35 pharmacologic agents. In the process of studying CYP2D6 we identified phenotype-genotype discordance in two individualsExpand
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