Zanamivir

Known as: 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid, 5-acetylamino-4-guanidino-6-(1,2,3-trihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid, 2,3-Didehydro-2,4-Dideoxy-4-Guanidinyl-N-Acetylneuraminic Acid 
A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been… (More)
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Highly Cited
2003
Highly Cited
2003
The influenza virus neuraminidase (NA) inhibitors zanamivir and oseltamivir were introduced into clinical practice in various… (More)
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Highly Cited
2001
Highly Cited
2001
The orally administered neuraminidase (NA) inhibitor RWJ-270201 was tested in parallel with zanamivir and oseltamivir against a… (More)
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Highly Cited
2001
Highly Cited
2001
RWJ-270201 is a novel cyclopentane inhibitor of influenza A and B virus neuraminidases (NAs). We compared the ability of RWJ… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND As prophylaxis against influenza in families, amantadine and rimantadine have had inconsistent effectiveness, partly… (More)
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Highly Cited
1999
Highly Cited
1999
CONTEXT The neuraminidase inhibitor zanamivir, a sialic acid analog administered directly to the respiratory tract, has been… (More)
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Highly Cited
1998
Highly Cited
1998
Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza. During prolonged treatment with zanamivir… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The sialic acid analogue zanamivir (GG167) is a selective inhibitor of influenza A and B virus neuraminidases. These… (More)
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Highly Cited
1991
Highly Cited
1991
1. We have developed a 19-compartment cable model of a guinea pig CA3 pyramidal neuron. Each compartment is allowed to contain… (More)
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Highly Cited
1979
Highly Cited
1979
1. Voltage-clamp studies were carried out on single rabbit myelinated nerve fibres at 14 degrees C with the method of Dodge… (More)
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