• Publications
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Evolution and ecology of influenza A viruses.
Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts, but recent studies in bats have suggested other reservoir species may also exist. Expand
A DNA transfection system for generation of influenza A virus from eight plasmids.
An eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA facilitates the design and recovery of both recombinant and reassortant influenza A viruses, and may also be applicable to the recovery of other RNA viruses entirely from cloning cDNA. Expand
Avian flu: H5N1 virus outbreak in migratory waterfowl
Cases of disease caused by H5N1 and transmission of the virus among migratory geese populations in western China are described and this outbreak may help to spread the virus over and beyond the Himalayas. Expand
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
The results suggest transmission of the virus from infected chickens to the child without another intermediate mammalian host acting as a "mixing vessel" illustrates the importance of intensive global influenza surveillance. Expand
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control.
  • H Chen, G. Smith, +25 authors Y. Guan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 21 February 2006
It is reported that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H3N2 virus from apparently healthy migratory birds in southern China. Expand
The evolution of H5N1 influenza viruses in ducks in southern China.
It is demonstrated that H5N1 influenza viruses, isolated from apparently healthy domestic ducks in mainland China from 1999 through 2002, were becoming progressively more pathogenic for mammals, and a hypothesis explaining the mechanism is presented. Expand
Influenza A viruses of migrating wild aquatic birds in North America.
Surveillance of North America's wild ducks and shorebirds for 26 and 16 years revealed differences in the prevalence of orthomyxoviruses between these hosts suggesting that shorebirds are the leading source of some viruses (such as H5) which are isolated less frequently from wild ducks. Expand
Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
A structural basis for the hypothesis that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics is demonstrated. Expand
Association of RIG-I with innate immunity of ducks to influenza
It is found that RIG-I expression is induced 200 fold, early in an innate immune response in ducks challenged with the H5N1 virus A/Vietnam/1203/04, which opens the possibility of increasing influenza resistance through creation of a transgenic chicken. Expand
Intestinal influenza: Replication and characterization of influenza viruses in ducks
The susceptibility of ducks to infection with human and avian strains of influenza virus and the possibility of transmission to animal species through the water supply suggests that ducks may be important in the ecology of influenza viruses. Expand