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R 125489

Known as: R-125489, R125489 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Zanamivir
analogs & derivatives

Narrower (2)

laninamivirlaninamivir octanoate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Neuraminidase inhibitor R-125489--a promising drug for treating influenza virus: steered molecular dynamics approach.
  • B. Mai, M. S. Li
  • Biochemical and biophysical research…
  • 2011
    • Corpus ID: 2627851
Two neuraminidase inhibitors, oseltamivir and zanamivir, are important drug treatments for influenza. Oseltamivir-resistant… Expand
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Highly Cited
2010
Highly Cited
2010
Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro.
BACKGROUND Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the… Expand
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Highly Cited
2010
Highly Cited
2010
Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration
ABSTRACT Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for use… Expand
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Highly Cited
2010
Highly Cited
2010
Assessment of Pandemic and Seasonal Influenza A (H1N1) Virus Susceptibility to Neuraminidase Inhibitors in Three Enzyme Activity Inhibition Assays
ABSTRACT The neuraminidase inhibitors (NAIs) zanamivir and oseltamivir are currently the only antiviral drugs effective for the… Expand
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Highly Cited
2010
Highly Cited
2010
Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses
Currently, two neuraminidase (NA) inhibitors, oseltamivir and zanamivir, which must be administrated twice daily for 5 days for… Expand
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2010
2010
Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats
CS-8958, a prodrug of laninamivir (R-125489), is currently under development as an inhaled anti-influenza drug. In this study… Expand
Review
2010
Review
2010
Laninamivir and its Prodrug, CS-8958: Long-Acting Neuraminidase Inhibitors for the Treatment of Influenza
  • M. Yamashita
  • Antiviral chemistry & chemotherapy
  • 2010
    • Corpus ID: 6155646
Oseltamivir and zanamivir are currently licensed worldwide for influenza treatment and chemoprophylaxis. Both drugs require twice… Expand
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Highly Cited
2009
Highly Cited
2009
CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract
ABSTRACT CS-8958 is a prodrug of the pharmacologically active form R-125489, a selective neuraminidase inhibitor, and has long… Expand
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Highly Cited
2008
Highly Cited
2008
CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity
ABSTRACT Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for the… Expand
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2004
2004
R-118958, a unique anti-influenza agent showing high efficacy for both prophylaxis and treatment after a single administration: from the in vitro stage to phase I study
Abstract R-118958 is a prodrug of R-125489, which is a neuraminidase inhibitor that potently inhibits influenza A and B viral… Expand
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