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R 125489
Known as:
R-125489
, R125489
National Institutes of Health
Create Alert
Related topics
Related topics
4 relations
Broader (1)
Zanamivir
analogs & derivatives
Narrower (2)
laninamivir
laninamivir octanoate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Neuraminidase inhibitor R-125489--a promising drug for treating influenza virus: steered molecular dynamics approach.
B. Mai
,
M. S. Li
Biochemical and biophysical research…
2011
Corpus ID: 2627851
Two neuraminidase inhibitors, oseltamivir and zanamivir, are important drug treatments for influenza. Oseltamivir-resistant…
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Highly Cited
2010
Highly Cited
2010
Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro.
L. Gubareva
,
A. Trujillo
,
+9 authors
A. Klimov
Antiviral therapy
2010
Corpus ID: 10148384
BACKGROUND Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the…
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Highly Cited
2010
Highly Cited
2010
Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration
S. Kubo
,
T. Tomozawa
,
M. Kakuta
,
A. Tokumitsu
,
M. Yamashita
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 10527701
ABSTRACT Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for use…
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Highly Cited
2010
Highly Cited
2010
Assessment of Pandemic and Seasonal Influenza A (H1N1) Virus Susceptibility to Neuraminidase Inhibitors in Three Enzyme Activity Inhibition Assays
H. T. Nguyen
,
Tiffany G Sheu
,
V. Mishin
,
A. Klimov
,
L. Gubareva
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 3389525
ABSTRACT The neuraminidase inhibitors (NAIs) zanamivir and oseltamivir are currently the only antiviral drugs effective for the…
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Highly Cited
2010
Highly Cited
2010
Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses
M. Kiso
,
S. Kubo
,
+4 authors
Y. Kawaoka
PLoS pathogens
2010
Corpus ID: 15720390
Currently, two neuraminidase (NA) inhibitors, oseltamivir and zanamivir, which must be administrated twice daily for 5 days for…
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2010
2010
Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats
K. Koyama
,
M. Takahashi
,
+6 authors
O. Okazaki
Xenobiotica; the fate of foreign compounds in…
2010
Corpus ID: 207426827
CS-8958, a prodrug of laninamivir (R-125489), is currently under development as an inhaled anti-influenza drug. In this study…
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Review
2010
Review
2010
Laninamivir and its Prodrug, CS-8958: Long-Acting Neuraminidase Inhibitors for the Treatment of Influenza
M. Yamashita
Antiviral chemistry & chemotherapy
2010
Corpus ID: 6155646
Oseltamivir and zanamivir are currently licensed worldwide for influenza treatment and chemoprophylaxis. Both drugs require twice…
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Highly Cited
2009
Highly Cited
2009
CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract
K. Koyama
,
M. Takahashi
,
+4 authors
O. Okazaki
Antimicrobial Agents and Chemotherapy
2009
Corpus ID: 22129573
ABSTRACT CS-8958 is a prodrug of the pharmacologically active form R-125489, a selective neuraminidase inhibitor, and has long…
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Highly Cited
2008
Highly Cited
2008
CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity
M. Yamashita
,
T. Tomozawa
,
M. Kakuta
,
A. Tokumitsu
,
H. Nasu
,
S. Kubo
Antimicrobial Agents and Chemotherapy
2008
Corpus ID: 45221260
ABSTRACT Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for the…
Expand
2004
2004
R-118958, a unique anti-influenza agent showing high efficacy for both prophylaxis and treatment after a single administration: from the in vitro stage to phase I study
M. Yamashita
2004
Corpus ID: 70538641
Abstract R-118958 is a prodrug of R-125489, which is a neuraminidase inhibitor that potently inhibits influenza A and B viral…
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