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Insights into the Interaction between Influenza Virus and Pneumococcus
  • J. McCullers
  • Medicine, Biology
  • Clinical Microbiology Reviews
  • 1 July 2006
SUMMARY Bacterial infections following influenza are an important cause of morbidity and mortality worldwide. Based on the historical importance of pneumonia as a cause of death during pandemicExpand
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Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.
Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality ofExpand
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The co-pathogenesis of influenza viruses with bacteria in the lung
  • J. McCullers
  • Medicine, Biology
  • Nature Reviews Microbiology
  • 1 April 2014
Concern that a highly pathogenic virus might cause the next influenza pandemic has spurred recent research into influenza and its complications. Bacterial superinfection in the lungs of peopleExpand
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Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor.
A lethal synergism exists between influenza virus and pneumococcus, which likely accounts for excess mortality from secondary bacterial pneumonia during influenza epidemics. Characterization of aExpand
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Mathematical model of a three-stage innate immune response to a pneumococcal lung infection.
Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcalExpand
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PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology
With the recent emergence of a novel pandemic strain, there is presently intense interest in understanding the molecular signatures of virulence of influenza viruses. PB1-F2 proteins fromExpand
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The Effects of Influenza A Virus PB1-F2 Protein on Polymerase Activity Are Strain Specific and Do Not Impact Pathogenesis
ABSTRACT The influenza A virus PB1-F2 protein has been implicated as a virulence factor, but the mechanism by which it enhances pathogenicity is not understood. The PB1 gene segment of the H1N1Expand
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Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae.
A lethal synergism exists between influenza virus and Streptococcus pneumoniae, accounting for excess mortality during influenza epidemics. Using a model of viral-bacterial synergism, we assessed theExpand
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N-Linked Glycosylation Attenuates H3N2 Influenza Viruses
ABSTRACT Over the last four decades, H3N2 subtype influenza A viruses have gradually acquired additional potential sites for glycosylation within the globular head of the hemagglutinin (HA) protein.Expand
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Impaired wound healing predisposes obese mice to severe influenza virus infection.
For the first time, obesity appeared as a risk factor for developing severe 2009 pandemic influenza infection. Given the increase in obesity, there is a need to understand the mechanisms underlyingExpand
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