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ZD 9331

Known as: BGC 9331, ZD9331, ZD-9331 
 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… Expand
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Review
2003
Review
2003
Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5… Expand
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Highly Cited
2002
Highly Cited
2002
Thymidylate synthase (TS) is a critical target for chemotherapeutic agents such as 5-fluorouracil (5-FU) and antifolates such as… Expand
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Review
2002
Review
2002
Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA… Expand
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Highly Cited
2001
Highly Cited
2001
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… Expand
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Highly Cited
2001
Highly Cited
2001
Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… Expand
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Review
2000
Review
2000
Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has… Expand
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Highly Cited
2000
Highly Cited
2000
Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS… Expand
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Highly Cited
1997
Highly Cited
1997
ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of… Expand
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Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand
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