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ZD 9331

Known as: BGC 9331, ZD9331, ZD-9331 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsQuinazolines
Plevitrexedtopotecan/ZD9331

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Antifolates targeted specifically to the folate receptor.
Highly Cited
2004
Highly Cited
2004
Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier
Studies were undertaken to characterize a low pH transport activity in a reduced folate carrier (RFC)-null HeLa-derived cell line… 
Review
2003
Review
2003
Novel antifolate drugs
Antimetabolites are active chemotherapeutic agents for many solid tumor and hematologic malignancies. Folate antagonists, purine… 
Review
2003
Review
2003
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside
Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5… 
Highly Cited
2002
Highly Cited
2002
The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
Thymidylate synthase (TS) is a critical target for chemotherapeutic agents such as 5-fluorouracil (5-FU) and antifolates such as… 
Highly Cited
2002
Highly Cited
2002
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines.
We have studied the molecular basis of resistance of multiple human leukaemia CCRF-CEM sublines to the novel antifolates ZD9331… 
Highly Cited
2001
Highly Cited
2001
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Highly Cited
2001
Highly Cited
2001
Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… 
Highly Cited
1997
Highly Cited
1997
Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of… 
Review
1996
Review
1996
Thymidylate synthase inhibitors.
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures… 
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