Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ZD 9331

Known as: BGC 9331, ZD9331, ZD-9331 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Review
2003
Review
2003
Antimetabolites are active chemotherapeutic agents for many solid tumor and hematologic malignancies. Folate antagonists, purine… Expand
Review
2003
Review
2003
Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5… Expand
  • figure 1
  • figure 2
  • figure 3
Highly Cited
2002
Highly Cited
2002
Thymidylate synthase (TS) is a critical target for chemotherapeutic agents such as 5-fluorouracil (5-FU) and antifolates such as… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Review
2002
Review
2002
Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA… Expand
Highly Cited
2001
Highly Cited
2001
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… Expand
Highly Cited
2001
Highly Cited
2001
Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Review
2000
Review
2000
Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has… Expand
  • figure I
  • figure 2
  • figure 3
Highly Cited
1997
Highly Cited
1997
ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of… Expand
  • figure I
  • figure 2
  • figure 3
  • table 2
  • table 4
Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand
  • figure 1
  • figure 2