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Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… Expand Antimetabolites are active chemotherapeutic agents for many solid tumor and hematologic malignancies. Folate antagonists, purine… Expand Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5… Expand Thymidylate synthase (TS) is a critical target for chemotherapeutic agents such as 5-fluorouracil (5-FU) and antifolates such as… Expand Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA… Expand Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… Expand Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… Expand Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has… Expand ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of… Expand The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand