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N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d… Expand Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological management of several tumors. Two… Expand Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were… Expand Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) have found clinical utility… Expand Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor… Expand 4231 Background: Plevitrexed (Px) is a novel thymidylate synthase inhibitor (TSI) that is taken up via the α-folate receptor as… Expand BGC 945 is a cyclopenta[g]quinazoline–based, thymidylate synthase inhibitor specifically transported into A-folate receptor (A-FR… Expand Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand