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Plevitrexed

Known as: (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid, Vamidex, Vamydex 
An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential… Expand
National Institutes of Health

Papers overview

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2013
2013
N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d… Expand
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Review
2010
Review
2010
  • Adam Jarmula
  • Mini reviews in medicinal chemistry
  • 2010
  • Corpus ID: 38800785
Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological management of several tumors. Two… Expand
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2008
2008
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were… Expand
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Review
2008
Review
2008
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) have found clinical utility… Expand
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2007
2007
  • 2007
  • Corpus ID: 195105194
 
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2006
2006
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data the… Expand
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Highly Cited
2005
Highly Cited
2005
BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor… Expand
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2005
2005
4231 Background: Plevitrexed (Px) is a novel thymidylate synthase inhibitor (TSI) that is taken up via the α-folate receptor as… Expand
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2005
2005
BGC 945 is a cyclopenta[g]quinazoline–based, thymidylate synthase inhibitor specifically transported into A-folate receptor (A-FR… Expand
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2003
2003
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
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