Plevitrexed

Known as: (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid, Vamidex, Vamydex 
An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2013
0120052013

Papers overview

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2013
2013
N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d… (More)
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Review
2010
Review
2010
Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological management of several tumors. Two… (More)
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2008
2008
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were… (More)
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Review
2008
Review
2008
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) have found clinical utility… (More)
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Review
2007
Review
2007
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) have found clinical utility… (More)
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2005
2005
BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor… (More)
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