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Plevitrexed

Known as: (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid, Vamidex, Vamydex 
An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d… Expand
Review
2010
Review
2010
  • A. Jarmuła
  • Mini reviews in medicinal chemistry
  • 2010
  • Corpus ID: 38800785
Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological management of several tumors. Two… Expand
2008
2008
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were… Expand
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Review
2008
Review
2008
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR) have found clinical utility… Expand
2007
Highly Cited
2006
Highly Cited
2006
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
Highly Cited
2005
Highly Cited
2005
BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor… Expand
2005
2005
4231 Background: Plevitrexed (Px) is a novel thymidylate synthase inhibitor (TSI) that is taken up via the α-folate receptor as… Expand
2005
2005
BGC 945 is a cyclopenta[g]quinazoline–based, thymidylate synthase inhibitor specifically transported into A-folate receptor (A-FR… Expand
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2003
2003
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand