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A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
- T. R. Jones, A. Calvert, A. Jackman, S. Brown, M. Jones, K. Harrap
- Biology, ChemistryEuropean journal of cancer
- 1981
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
- G. Westerhof, J. Schornagel, H. Pinedo
- Biology, ChemistryMolecular pharmacology
- 1 September 1995
TLDR
HPV16 E6 augments Wnt signaling in an E6AP-dependent manner.
- H. Lichtig, D. Gilboa, L. Sherman
- BiologyVirology
- 5 January 2010
Folate-based thymidylate synthase inhibitors as anticancer drugs.
- A. Jackman, A. Calvert
- Biology, ChemistryAnnals of oncology : official journal of the…
- 1 November 1995
TLDR
bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.
- T. Fisher, A. Milner, J. Hickman
- Biology, ChemistryCancer research
- 15 July 1993
TLDR
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6.
- H. Lichtig, Meirav Algrisi, L. Sherman
- BiologyVirology
- 20 June 2006
ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer.
- A. Jackman, D. Farrugia, F. T. Boyle
- Biology, MedicineEuropean journal of cancer
- 1 July 1995
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
- D. Gibbs, D. Theti, A. Jackman
- Biology, ChemistryCancer research
- 15 December 2005
TLDR
Comparative expressed sequence hybridization to chromosomes for tumor classification and identification of genomic regions of differential gene expression
- Y. Lu, D. Williamson, J. Shipley
- BiologyProceedings of the National Academy of Sciences…
- 31 July 2001
TLDR
ICI D1694, an inhibitor of thymidylate synthase for clinical study.
- A. Jackman, D. Jodrell, W. Gibson, T. Stephens
- Biology, MedicineAdvances in experimental medicine and biology
- 1991
The TS inhibitor, ICI D1694, is a highly potent inhibitor of tumour growth in vitro and in vivo. Uptake via the RFC and rapid metabolism to polyglutamate forms appear to be responsible for potency.…
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