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XRCC4 gene

Known as: X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 4, X-ray repair complementing defective repair in Chinese hamster cells 4, X-ray repair, complementing defective, repair in Chinese hamster 
This gene plays a role in the repair of double-strand DNA breaks and V(D)J recombination.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double… Expand
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Highly Cited
2009
Highly Cited
2009
XLF-Cernunnos (XLF) is a component of the DNA ligase IV-XRCC4 (LX) complex, which functions during DNA non-homologous end joining… Expand
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Highly Cited
2007
Highly Cited
2007
XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is… Expand
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Highly Cited
2006
Highly Cited
2006
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects… Expand
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Highly Cited
2006
Highly Cited
2006
Poly(ADP-ribose)polymerase 1 (PARP-1) recognizes DNA strand interruptions in vivo and triggers its own modification as well as… Expand
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Highly Cited
2004
Highly Cited
2004
Ataxia-oculomotor apraxia 1 (AOA1) is an autosomal recessive neurodegenerative disease that is reminiscent of ataxia… Expand
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Highly Cited
2000
Highly Cited
2000
XRCC4 is a non-homologous end-joining protein employed in DNA double strand break repair and in V(D)J recombination. In mice… Expand
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Highly Cited
1998
Highly Cited
1998
XRCC4 was identified via a complementation cloning method that employed an ionizing radiation (IR)-sensitive hamster cell line… Expand
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Highly Cited
1997
Highly Cited
1997
Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Mammalian cells deficient in the XRCC4 DNA repair protein are impaired in DNA double-strand break repair and are… Expand
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