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XRCC4 gene

Known as: X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 4, X-ray repair complementing defective repair in Chinese hamster cells 4, X-ray repair, complementing defective, repair in Chinese hamster 
This gene plays a role in the repair of double-strand DNA breaks and V(D)J recombination.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDouble Strand Break RepairNon-Homologous DNA End-JoiningV(D)J Recombination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase
XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold… 
Highly Cited
2009
Highly Cited
2009
Significant association of ERCC6 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan.
AIM To evaluate the association between the polymorphisms of the ERCC6 DNA repair gene, which plays an important role in… 
Highly Cited
2008
Highly Cited
2008
Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.
BACKGROUND The DNA repair gene XRCC4, an important caretaker of overall genome stability, is thought to play a major role in the… 
2008
2008
Enhanced Use of Backup Pathways of NHEJ in G2 in Chinese Hamster Mutant Cells with Defects in the Classical Pathway of NHEJ
Abstract Wu, W., Wang, M., Mussfeldt, T. and Iliakis, G. Enhanced Use of Backup Pathways of NHEJ in G2 in Chinese Hamster Mutant… 
Highly Cited
2007
Highly Cited
2007
The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.
Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two… 
Highly Cited
2007
Highly Cited
2007
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4.
2007
2007
Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.
In addition to linking nicked/fragmented DNA molecules back into a contiguous duplex, DNA ligases also have the capacity to… 
Highly Cited
2004
Highly Cited
2004
End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4.
2002
2002
Identification of Human Autoantibodies to the DNA Ligase IV/XRCC4 Complex and Mapping of an Autoimmune Epitope to a Potential Regulatory Region1
The nonhomologous end-joining pathway is the principal mechanism for repair of ionizing radiation-induced, double-strand breaks… 
Highly Cited
1999
Highly Cited
1999
A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events.
Eukaryotic repair of double-strand DNA breaks can occur either by homologous recombination or by nonhomologous DNA end joining… 
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