XRCC4 gene

Known as: X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 4, X-ray repair complementing defective repair in Chinese hamster cells 4, X-ray repair, complementing defective, repair in Chinese hamster 
This gene plays a role in the repair of double-strand DNA breaks and V(D)J recombination.

Topic mentions per year

Topic mentions per year

1990-2017
010203019902017

Papers overview

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Highly Cited
2007
Highly Cited
2007
V(D)J recombination and immunoglobulin class switch recombination (CSR) are two somatic rearrangement mechanisms that proceed… (More)
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Highly Cited
2006
Highly Cited
2006
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects… (More)
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Highly Cited
2006
Highly Cited
2006
Inactivation of the XRCC4 nonhomologous end-joining factor in the mouse germ line leads to embryonic lethality, in association… (More)
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Highly Cited
2004
Highly Cited
2004
Ataxia-oculomotor apraxia 1 (AOA1) is an autosomal recessive neurodegenerative disease that is reminiscent of ataxia… (More)
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1999
1999
XR-1 is a CHO mutant cell line defective in double strand break repair and V(D)J recombination. These defects are due to a… (More)
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Highly Cited
1998
Highly Cited
1998
The Ku86 and XRCC4 proteins perform critical but poorly understood functions in the repair of DNA double-strand breaks. Both Ku… (More)
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1998
1998
The gene product of XRCC4 has been implicated in both V(D)J recombination and the more general process of double strand break… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Mammalian cells deficient in the XRCC4 DNA repair protein are impaired in DNA double-strand break repair and are… (More)
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Highly Cited
1997
Highly Cited
1997
Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination… (More)
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Highly Cited
1995
Highly Cited
1995
The XR-1 Chinese hamster ovary cell line is impaired in DNA double-strand break repair (DSBR) and in ability to support V(D)J… (More)
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