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XPO1 gene

Known as: CRM1, chromosome region maintenance 1 homolog (yeast), Exportin 1 (CRM1 Homolog, Yeast) Gene 
This gene plays a role in the regulation of nuclear export.
National Institutes of Health

Related topics

Related topics

9 relations
Homo sapiensIntracellular TransportLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Characterization of inhibition reveals distinctive properties for human and Saccharomyces cerevisiae CRM1.
The receptor CRM1 is responsible for the nuclear export of many tumor-suppressor proteins and viral ribonucleoproteins. This… 
2017
2017
Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway
ABSTRACT Epithelial ovarian cancer is prone to metastasizing at an early stage, but their mechanisms remain unclear. CRM1 is an… 
2014
2014
Cooperativity among Rev-Associated Nuclear Export Signals Regulates HIV-1 Gene Expression and Is a Determinant of Virus Species Tropism
ABSTRACT Murine cells exhibit a profound block to HIV-1 virion production that was recently mapped to a species-specific… 
Review
2013
Review
2013
Targeting the nuclear transport machinery by rational drug design.
CRM1 (also referred as exportin1 or Xpo1) is a key member of the importin β superfamily of nuclear transport receptors. Its… 
2013
2013
First-in-class, first-in-human phase I trial of KPT-330, a selective inhibitor of nuclear export (SINE) in patients (pts) with advanced solid tumors.
2505 Background: In cancers, the majority of tumor suppressor proteins (TSP) are transported out of the nucleus exclusively by… 
2008
2008
Assembly of the Trypanosoma brucei 60S Ribosomal Subunit Nuclear Export Complex Requires Trypanosome-Specific Proteins P34 and P37
ABSTRACT We previously identified two Trypanosoma brucei RNA binding proteins, P34 and P37, and determined that they are… 
Highly Cited
2004
Highly Cited
2004
A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress*
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein with glycolytic and non-glycolytic functions… 
2002
2002
Rev Inhibition Strongly Affects Intracellular Distribution of Human Immunodeficiency Virus Type 1 RNAs
ABSTRACT To define the human immunodeficiency virus type 1 (HIV-1) RNA maturation pathways, we analyzed the intracellular… 
2001
2001
A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin beta, CRM1 and RanBP1.
Transport of macromolecules between the nucleus and cytoplasm involves the recognition of intrinsic localization signals by… 
Highly Cited
1981
Highly Cited
1981
Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates
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