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Natural RNA circles function as efficient microRNA sponges
TLDR
This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner. Expand
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
TLDR
This study provides the first evidence for non‐coding antisense transcripts as functional miRNA targets, and a novel regulatory mechanism involving a positive correlation between mRNA and antisense circular RNA levels. Expand
The Specificity of the CRM1-Rev Nuclear Export Signal Interaction Is Mediated by RanGTP*
TLDR
The data are consistent with a model in which CRM1 is the nuclear export receptor for the Rev-RRE ribonucleoprotein complex and that RanGTP binds to a preformed Rev-CRM1 complex and specifies a functional interaction with the NES. Expand
Self-assembly of a nanoscale DNA box with a controllable lid
TLDR
The DNA origami method is extended into three dimensions by creating an addressable DNA box that can be opened in the presence of externally supplied DNA ‘keys’, and controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications. Expand
Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.
TLDR
The findings reported here indicate that several miRNAs are differentially regulated in bladder cancer and may form a basis for clinical development of new biomarkers for bladder cancer. Expand
Comparison of circular RNA prediction tools
TLDR
This study uses common RNAseq datasets to scrutinize and compare the output from five different algorithms; circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice and evaluates the levels of bona fide and false positive circRNAs based on RNase R resistance. Expand
Circular RNA and miR-7 in cancer.
TLDR
The current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways is reviewed and possible models explaining the relevance of coexpressing miR- 7 along with a circRNA inhibitor are discussed. Expand
Evaluating the accuracy of SHAPE-directed RNA secondary structure predictions
TLDR
This work evaluates the extent and nature of improvements in data-directed predictions for a diverse set of 16S/18S ribosomal sequences using a stochastic model of experimental SHAPE data and confirms sequence dependencies in the directability of thermodynamic predictions and investigates the potential for greater accuracy improvements in the worst performing test sequence. Expand
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.
TLDR
Effective in vivo RNA interference was achieved in bronchiole epithelial cells of transgenic EGFP mice after nasal administration of chitosan/siRNA formulations (37% and 43% reduction compared to mismatch and untreated control, respectively). Expand
Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development
TLDR
It is demonstrated that circRNAs are highly abundant and dynamically expressed in a spatio-temporal manner in porcine fetal brain, suggesting important functions during mammalian brain development. Expand
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