X-Linked Combined Immunodeficiency Diseases

Known as: SCID, X Linked, X-SCID, Immunodeficiency Diseases, X-Linked Combined 
Forms of combined immunodeficiency caused by mutations in the gene for INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT. Both severe and non-severe subtypes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2017
05101519872017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
BACKGROUND Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Severe combined immunodeficiency (SCID) is caused by multiple genetic defects. The most common form of SCID, X-linked SCID (XSCID… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The common gamma chain (gamma c) of the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors is defective in humans with XSCID. Mice… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The interleukin 2 receptor gamma chain (IL-2R gamma) is a component of the receptors for IL-2, IL-4, IL-7, and IL-15. Mutations… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor gamma chain (gamma c… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is a component of high and intermediate affinity IL-2 receptors that… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The gene encoding the gamma chain of the lymphocyte interleukin-2 receptor has been cloned and shown to be required to associate… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The interleukin-2 receptor gamma chain (IL-2R gamma) is a necessary component of functional IL-2 receptors. IL-2R gamma mutations… (More)
Is this relevant?