Agammaglobulinemia

Known as: Agammaglobulinemia [Disease/Finding], Agammaglobulinemia NOS, Agammaglobulinaemia 
An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Whole exome sequencing was used to determine the causative gene in patients with B cell defects of unknown etiology. A homozygous… (More)
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Review
2011
Review
2011
Intravenous immunoglobulin (IVIG) is a therapeutic compound prepared from pools of plasma obtained from several thousand healthy… (More)
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Highly Cited
2006
Highly Cited
2006
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by mutations in the gene for Bruton tyrosine kinase (BTK… (More)
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2006
2006
No clear genotype/phenotype correlations have been established in patients with X-linked agammaglobulinemia (XLA). To determine… (More)
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2003
2003
We have undertaken a retrospective study of antibody deficient patients, with and without lymphoma, and assessed the ability of… (More)
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Highly Cited
1998
Highly Cited
1998
B cell precursors transiently express a pre-B cell receptor complex consisting of a rearranged mu heavy chain, a surrogate light… (More)
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Highly Cited
1996
Highly Cited
1996
Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide… (More)
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Highly Cited
1995
Highly Cited
1995
Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X… (More)
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Highly Cited
1995
Highly Cited
1995
The X-ray crystal structure of the high affinity complex between the pleckstrin homology (PH) domain from rat phospholipase C… (More)
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Highly Cited
1993
Highly Cited
1993
X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of pre-B cells in the bone marrow to develop… (More)
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