Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Agammaglobulinemia

Known as: Agammaglobulinemia [Disease/Finding], Agammaglobulinemia NOS, Agammaglobulinaemia 
An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Abstract: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by mutations in the gene for Bruton tyrosine… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Bruton's tyrosine kinase (Btk) is an enzyme which is involved in maturation of B cells. It is a target for mutations causing X… Expand
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The X-ray crystal structure of the high affinity complex between the pleckstrin homology (PH) domain from rat phospholipase C… Expand
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1993
Highly Cited
1993
X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of pre-B cells in the bone marrow to develop… Expand
Is this relevant?
Highly Cited
1993
Highly Cited
1993
IN Fig. 2b of this article, the sizing of DNA fragments was incorrect. The corrected sizes are shown below, together with the… Expand
Is this relevant?
Highly Cited
1992
Highly Cited
1992
The human androgen-receptor gene (HUMARA; GenBank) contains a highly polymorphic trinucleotide repeat in the first exon. We have… Expand
Is this relevant?
Highly Cited
1975
Highly Cited
1975
Of 18 boys in Duncan kindred, 6 died of a lymphoproliferative disease. They exhibited a subtle, progressive combined variable… Expand
Is this relevant?
Highly Cited
1969
Highly Cited
1969
Malignant lymphomas developed in 5 renal homograft recipients treated at 3 widely separated transplantation centers. The… Expand
  • figure I
  • figure 2
  • figure 3
Is this relevant?