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Severe Combined Immunodeficiency

Known as: severe combined immunodeficiency disease, Immunodeficiency Syndrome, Severe Combined, combined immunodeficiency severe 
A rare, inherited disease that is marked by a lack of B lymphocytes (white blood cells that make antibodies and help fight infections) and a lack of… Expand
National Institutes of Health

Related topics

Related topics

46 relations
ADA geneADENOSINE DEAMINASEAdenosine deaminase deficiencyBare Lymphocyte Syndrome
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Narrower (11)

AGAMMAGLOBULINEMIA, LYMPHOPENICBare lymphocyte syndrome 2Immune dysfunction with T-cell inactivation due to calcium entry defect 2Omenn Syndrome
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Broader (2)

Immunologic Deficiency Syndromesinborn immunodeficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Efficacy of gene therapy for X-linked severe combined immunodeficiency.
BACKGROUND The outcomes of gene therapy to correct congenital immunodeficiencies are unknown. We reviewed long-term outcomes… Expand
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Highly Cited
2004
Highly Cited
2004
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
BACKGROUND X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine-receptor gamma chain… Expand
  • table 1
Highly Cited
2003
Highly Cited
2003
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.
To the Editor: We recently reported (April 18 issue)1 the sustained correction of X-linked severe combined immunodeficiency… Expand
Highly Cited
2002
Highly Cited
2002
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
BACKGROUND X-linked severe combined immunodeficiency due to a mutation in the gene encoding the common gamma (gamma(c)) chain is… Expand
Highly Cited
2000
Highly Cited
2000
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
Severe combined immunodeficiency-X1 (SCID-X1) is an X-linked inherited disorder characterized by an early block in T and natural… Expand
Highly Cited
1999
Highly Cited
1999
Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
BACKGROUND Since 1968 it has been known that bone marrow transplantation can ameliorate severe combined immunodeficiency, but… Expand
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Highly Cited
1998
Highly Cited
1998
Defective IL7R expression in T-B+NK + severe combined immunodeficiency
Severe combined immunodeficiency (SCID) is caused by multiple genetic defects. The most common form of SCID, X-linked SCID (XSCID… Expand
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Review
1992
Review
1992
The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description.
The history, rationale, and development of the Structured Clinical Interview for DSM-III-R (SCID) is described. The SCID is a… Expand
Highly Cited
1988
Highly Cited
1988
Transfer of a functional human immune system to mice with severe combined immunodeficiency
The pressing need for a better experimental system for AIDS research has brought into sharp focus the shortcomings of available… Expand
Highly Cited
1983
Highly Cited
1983
A severe combined immunodeficiency mutation in the mouse
The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the… Expand
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