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Severe Combined Immunodeficiency

Known as: severe combined immunodeficiency disease, Immunodeficiency Syndrome, Severe Combined, combined immunodeficiency severe 
A rare, inherited disease that is marked by a lack of B lymphocytes (white blood cells that make antibodies and help fight infections) and a lack of… 
National Institutes of Health

Related topics

Related topics

46 relations
ADA geneADENOSINE DEAMINASEAdenosine deaminase deficiencyBare Lymphocyte Syndrome

Narrower (11)

AGAMMAGLOBULINEMIA, LYMPHOPENICBare lymphocyte syndrome 2Immune dysfunction with T-cell inactivation due to calcium entry defect 2Omenn Syndrome

Broader (2)

Immunologic Deficiency Syndromesinborn immunodeficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Immune deficiencies , infection , and systemic immune disorders Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe : Entering a new century…
Andrew R. Gennery, MD,* Mary A. Slatter, MD,* Laure Grandin, MSc, Pierre Taupin, MD, Andrew J. Cant, FRCP, Paul Veys, FRCP… 
Highly Cited
2007
Highly Cited
2007
Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency.
Retroviral gene therapy can restore immunity to infants with X-linked severe combined immunodeficiency (XSCID) caused by… 
Highly Cited
2003
Highly Cited
2003
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-one (ARC-111, topovale) is a… 
Highly Cited
2000
Highly Cited
2000
Performance Evaluation of a Combined Input- and Crosspoint-Queued Switch
This letter proposes a combined inputand crosspoint-queued (CIC) switch in which virtual output queuing (VOQ) is used at each… 
Highly Cited
1998
Highly Cited
1998
Enterohepatic lesions in SCID mice infected with Helicobacter bilis.
Helicobacter bilis is a recently identified species that colonizes the intestine and liver of mice. In immunocompetent mice… 
Highly Cited
1996
Highly Cited
1996
Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.
X-linked severe combined immunodeficiency (XSCID) is a lethal disease caused by a defect in the gene encoding the common gamma… 
Highly Cited
1994
Highly Cited
1994
Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.
Sindbis virus (SV) causes an acute encephalomyelitis in mice. A T cell-dependent inflammatory response is first detected 3 days… 
Review
1994
Review
1994
Bone marrow transplantation (BMT) in Europe for primary immunodeficiencies other than severe combined immunodeficiency: a report from the European Group for BMT and the European Group for…
Bone marrow (BM) transplantations performed between 1977 and 1991 at 13 European centers in 149 patients with 11 different… 
Highly Cited
1989
Highly Cited
1989
Growth of human tumors in immune-deficient scid mice and nude mice.
The ability to grow human tumors in immune-deficient mice offers offers many research opportunities (Sharkey and Fogh 1984). In… 
Highly Cited
1985
Highly Cited
1985
The function of antigen-presenting cells in mice with severe combined immunodeficiency.
We have examined the antigen-presenting function of spleen cells in the C.B-17 scid mouse, a mutation that severely impairs the… 
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