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Severe Combined Immunodeficiency

Known as: severe combined immunodeficiency disease, Immunodeficiency Syndrome, Severe Combined, combined immunodeficiency severe 
A rare, inherited disease that is marked by a lack of B lymphocytes (white blood cells that make antibodies and help fight infections) and a lack of… 
National Institutes of Health

Related topics

Related topics

46 relations
ADA geneADENOSINE DEAMINASEAdenosine deaminase deficiencyBare Lymphocyte Syndrome

Narrower (11)

AGAMMAGLOBULINEMIA, LYMPHOPENICBare lymphocyte syndrome 2Immune dysfunction with T-cell inactivation due to calcium entry defect 2Omenn Syndrome

Broader (2)

Immunologic Deficiency Syndromesinborn immunodeficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures
Bypassing estrogen receptor (ER) signaling during development of endocrine resistance remains the most common cause of disease… 
Highly Cited
2010
Highly Cited
2010
Immune deficiencies , infection , and systemic immune disorders Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe : Entering a new century…
Andrew R. Gennery, MD,* Mary A. Slatter, MD,* Laure Grandin, MSc, Pierre Taupin, MD, Andrew J. Cant, FRCP, Paul Veys, FRCP… 
Highly Cited
2000
Highly Cited
2000
Performance Evaluation of a Combined Input- and Crosspoint-Queued Switch
This letter proposes a combined inputand crosspoint-queued (CIC) switch in which virtual output queuing (VOQ) is used at each… 
Highly Cited
1997
Highly Cited
1997
Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora
Helicobacter bilis has been isolated from aged inbred mice with multifocal chronic hepatitis and from scid mice with diarrhea… 
Highly Cited
1996
Highly Cited
1996
IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum.
The protozoan parasite Cryptosporidium parvum (Cp) causes diarrhea that can be acutely severe in immunocompetent persons and can… 
Review
1995
Review
1995
The human immune system in hu-PBL-SCID mice.
Highly Cited
1994
Highly Cited
1994
Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.
Sindbis virus (SV) causes an acute encephalomyelitis in mice. A T cell-dependent inflammatory response is first detected 3 days… 
Highly Cited
1991
Highly Cited
1991
Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.
SCID-hu mice are heterochimeric animals that are constructed by transplanting human fetal thymus (Thy), liver (Liv), and/or lymph… 
Review
1989
Review
1989
Animal models of AIDS
Animal models of AIDS are essential for understanding the pathogenesis of retrovirus‐induced immune deficiency and encephalopathy… 
Highly Cited
1977
Highly Cited
1977
Chronic progressive poliomyelitis secondary to vaccination of an immunodeficient child.
We investigated an immunodeficient child in whom chronic progressive poliomyelitis developed after she had received live oral… 
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