FAQ

Severe Combined Immunodeficiency

Known as: severe combined immunodeficiency disease, Immunodeficiency Syndrome, Severe Combined, combined immunodeficiency severe 
A rare, inherited disease that is marked by a lack of B lymphocytes (white blood cells that make antibodies and help fight infections) and a lack of… (More)

Topic mentions per year

Topic mentions per year

1971-2017
010020019712017

Related topics

Related topics

39 relations
ADA geneADENOSINE DEAMINASEAdenosine deaminase deficiencyBare Lymphocyte Syndrome
(More)

Broader (2)

Immunologic Deficiency Syndromesinborn immunodeficiency

Narrower (7)

Omenn SyndromeReticular dysgenesisReticuloendotheliosis, X-linkedSevere combined immunodeficiency due to adenosine deaminase deficiency
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Severe Combined Immunodeficiency
radiotherapeutic
Immunologic Deficiency Syndromes
prevention & control
Microbiological
ADENOSINE DEAMINASE

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.
BACKGROUND X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine-receptor gamma chain… (More)
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Highly Cited
2003
Highly Cited
2003
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.
to the editor: We recently reported (April 18 issue) 1 the sustained correction of X-linked severe combined immunodeficiency… (More)
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Highly Cited
2002
Highly Cited
2002
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
BACKGROUND X-linked severe combined immunodeficiency due to a mutation in the gene encoding the common gamma (gamma(c)) chain is… (More)
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Highly Cited
2000
Highly Cited
2000
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
Severe combined immunodeficiency-X1 (SCID-X1) is an X-linked inherited disorder characterized by an early block in T and natural… (More)
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Highly Cited
1999
Highly Cited
1999
Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
BACKGROUND Since 1968 it has been known that bone marrow transplantation can ameliorate severe combined immunodeficiency, but… (More)
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Highly Cited
1998
Highly Cited
1998
Defective IL7R expression in T-B+NK + severe combined immunodeficiency
Severe combined immunodeficiency (SCID) is caused by multiple genetic defects. The most common form of SCID, X-linked SCID (XSCID… (More)
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Highly Cited
1994
Highly Cited
1994
Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.
A homozygous mutation in the kinase domain of ZAP-70, a T cell receptor-associated protein tyrosine kinase, produced a… (More)
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Highly Cited
1993
Highly Cited
1993
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.
The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is a component of high and intermediate affinity IL-2 receptors that… (More)
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Highly Cited
1988
Highly Cited
1988
Transfer of a functional human immune system to mice with severe combined immunodeficiency.
The pressing need for a better experimental system for AIDS research has brought into sharp focus the shortcomings of available… (More)
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Highly Cited
1983
Highly Cited
1983
A severe combined immunodeficiency mutation in the mouse.
The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the… (More)
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