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Severe Combined Immunodeficiency

Known as: severe combined immunodeficiency disease, Immunodeficiency Syndrome, Severe Combined, combined immunodeficiency severe 
A rare, inherited disease that is marked by a lack of B lymphocytes (white blood cells that make antibodies and help fight infections) and a lack of… 
National Institutes of Health

Related topics

Related topics

46 relations
ADA geneADENOSINE DEAMINASEAdenosine deaminase deficiencyBare Lymphocyte Syndrome

Narrower (11)

AGAMMAGLOBULINEMIA, LYMPHOPENICBare lymphocyte syndrome 2Immune dysfunction with T-cell inactivation due to calcium entry defect 2Omenn Syndrome

Broader (2)

Immunologic Deficiency Syndromesinborn immunodeficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Efficacy of gene therapy for X-linked severe combined immunodeficiency.
BACKGROUND The outcomes of gene therapy to correct congenital immunodeficiencies are unknown. We reviewed long-term outcomes… 
Highly Cited
2003
Highly Cited
2003
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.
To the Editor: We recently reported (April 18 issue)1 the sustained correction of X-linked severe combined immunodeficiency… 
Highly Cited
2002
Highly Cited
2002
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
BACKGROUND X-linked severe combined immunodeficiency due to a mutation in the gene encoding the common gamma (gamma(c)) chain is… 
Highly Cited
2000
Highly Cited
2000
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
Severe combined immunodeficiency-X1 (SCID-X1) is an X-linked inherited disorder characterized by an early block in T and natural… 
Highly Cited
1999
Highly Cited
1999
Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
BACKGROUND Since 1968 it has been known that bone marrow transplantation can ameliorate severe combined immunodeficiency, but… 
Highly Cited
1998
Highly Cited
1998
Defective IL7R expression in T-B+NK + severe combined immunodeficiency
Severe combined immunodeficiency (SCID) is caused by multiple genetic defects. The most common form of SCID, X-linked SCID (XSCID… 
Highly Cited
1993
Highly Cited
1993
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10…
Listeriosis in mice with the severe combined immunodeficiency (SCID) mutation is an established model in vivo and in vitro of… 
Review
1992
Review
1992
The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description.
The history, rationale, and development of the Structured Clinical Interview for DSM-III-R (SCID) is described. The SCID is a… 
Highly Cited
1988
Highly Cited
1988
Transfer of a functional human immune system to mice with severe combined immunodeficiency
The pressing need for a better experimental system for AIDS research has brought into sharp focus the shortcomings of available… 
Highly Cited
1983
Highly Cited
1983
A severe combined immunodeficiency mutation in the mouse
The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the… 
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