ADENOSINE DEAMINASE

Known as: Adenosine aminohydrolase, Adenosine Deaminase [Chemical/Ingredient], Aminohydrolase, Adenosine 
Adenosine deaminase (363 aa, ~41 kDa) is encoded by the human ADA gene. This protein plays a role in purine metabolism.
National Institutes of Health

Related topics

Related topics

24 relations
ADA geneADCP1 geneAdenine deaminaseAdenosine deaminase:CCnc:Pt:Plr fld:Qn
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Broader (1)

Aminohydrolases

Narrower (5)

Severe combined immunodeficiency due to adenosine deaminase deficiencyTadA protein, E coliadenosine deaminase activityadenosine deaminase-complexing protein, Oryctolagus cuniculus
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
BACKGROUND Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified… (More)
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Highly Cited
2006
Highly Cited
2006
Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.
Extracellular levels of adenosine increase during hypoxia. While acute increases in adenosine are important to counterbalance… (More)
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Highly Cited
2005
Highly Cited
2005
CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.
Adenosine deaminase (ADA), a protein whose deficit leads to severe combined immunodeficiency, binds to the cell surface by means… (More)
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Highly Cited
2005
Highly Cited
2005
A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans.
Slow, rhythmic oscillations (<5 Hz) in the sleep electroencephalogram may be a sign of synaptic plasticity occurring during sleep… (More)
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Review
1997
Review
1997
Cell surface adenosine deaminase: Much more than an ectoenzyme
During the last 10 years, adenosine deaminase (ADA), an enzyme considered to be cytosolic, has been found on the cell surface of… (More)
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Highly Cited
1996
Highly Cited
1996
RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase
Hepatitis delta virus (HDV) is a subviral human pathogen that requires hepatitis B virus (HBV) for packaging. Concurrent… (More)
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Highly Cited
1996
Highly Cited
1996
Adenosine deaminase (ADA) isoenzymes ADA1 and ADA2: diagnostic and biological role.
  • C. Gakis
  • The European respiratory journal
  • 1996
The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleosides: adenosine and 2… (More)
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Highly Cited
1993
Highly Cited
1993
Direct association of adenosine deaminase with a T cell activation antigen, CD26.
CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid… (More)
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Highly Cited
1993
Highly Cited
1993
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… (More)
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Highly Cited
1983
Highly Cited
1983
Adenosine deaminase in pleural fluids. Test for diagnosis of tuberculous pleural effusion.
Adenosine deaminase (ADA) activity was studied in 221 patients with pleuroperitoneal effusions. Patients were subdivided into the… (More)
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