FAQ

WRN protein, human

Known as: Werner Syndrome ATP-Dependent Helicase, RECQ3 protein, human, Werner syndrome helicase, human 
Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2016
02419982016

Related topics

Related topics

23 relations
3'-5'-ExonucleasesATP HydrolysisAdenosine TriphosphatasesBLM gene
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Broader (1)

Werner Syndrome Helicase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
WRN protein, human
Hydrolysis
Adenosine Triphosphatases
DNA Repair
DNA Replication
dna binding

Papers overview

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2015
2015
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers
Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair… (More)
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2010
2010
Acetylation of WRN Protein Regulates Its Stability by Inhibiting Ubiquitination
BACKGROUND WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been… (More)
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2010
2010
WRN participates in translesion synthesis pathway through interaction with NBS1.
Werner syndrome (WS), caused by mutation of the WRN gene, is an autosomal recessive disorder associated with premature aging and… (More)
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2006
2006
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
WRN is unique among the five human RecQ DNA helicases in having a functional exonuclease domain (WRN-exo) and being defective in… (More)
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2004
2004
The interaction of p53 with replication protein A mediates suppression of homologous recombination
The tumor suppressor protein p53 is emerging as a central regulator of homologous recombination (HR) processes and DNA… (More)
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2004
2004
The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.
The Werner syndrome protein, WRN, is a member of the RecQ family of DNA helicases. It possesses both 3'-->5' DNA helicase and 3… (More)
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2002
2002
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN… (More)
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2002
2002
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.
Werner syndrome is a premature aging disorder caused by the lack of an active Werner syndrome protein (WRN). The patients suffer… (More)
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Highly Cited
2001
Highly Cited
2001
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Werner syndrome (WS) is a human premature aging disorder characterized by chromosomal instability. The cellular defects of WS… (More)
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2001
2001
Evidence for a Replication Function of Ffa-1, the Xenopus Orthologue of Werner Syndrome Protein
DNA replication in higher eukaryotic cells occurs at a large number of discrete sites called replication foci. We have previously… (More)
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