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WRN protein, human
Known as:
Werner Syndrome ATP-Dependent Helicase
, RECQ3 protein, human
, Werner syndrome helicase, human
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Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP…
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National Institutes of Health
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Related topics
Related topics
23 relations
3'-5'-Exonucleases
ATP Hydrolysis
Adenosine Triphosphatases
BLM gene
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Broader (1)
Werner Syndrome Helicase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins
Gabrielle J. Grundy
,
S. Rulten
,
+5 authors
K. Caldecott
Nature Communications
2016
Corpus ID: 6966201
The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome…
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Highly Cited
2010
Highly Cited
2010
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
Francesca Ammazzalorso
,
L. Pirzio
,
M. Bignami
,
A. Franchitto
,
P. Pichierri
EMBO Journal
2010
Corpus ID: 31539522
Accurate response to replication arrest is crucial to preserve genome stability and requires both the ATR and ATM functions. The…
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Highly Cited
2006
Highly Cited
2006
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β
J. Harrigan
,
D. Wilson
,
+5 authors
V. Bohr
Nucleic Acids Research
2006
Corpus ID: 47165
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging disorder Werner syndrome (WS…
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Highly Cited
2006
Highly Cited
2006
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
W. Cheng
,
Rika Kusumoto
,
+7 authors
V. Bohr
Nucleic Acids Research
2006
Corpus ID: 6672191
Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitive to DNA interstrand cross-links (ICLs), whose…
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Highly Cited
2003
Highly Cited
2003
Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage
C. von Kobbe
,
J. Harrigan
,
+4 authors
V. Bohr
Molecular and Cellular Biology
2003
Corpus ID: 43679195
ABSTRACT A defect in the Werner syndrome protein (WRN) leads to the premature aging disease Werner syndrome (WS). Hallmark…
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Highly Cited
2002
Highly Cited
2002
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.
Baomin Li
,
L. Comai
Nucleic Acids Research
2002
Corpus ID: 37407821
The DNA-dependent protein kinase (DNA-PK) complex, which is composed of a DNA-dependent kinase subunit (DNA-PKcs) and the Ku70/80…
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Highly Cited
2001
Highly Cited
2001
Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex*
Baomin Li
,
L. Comai
Journal of Biological Chemistry
2001
Corpus ID: 36625067
Werner syndrome (WS) is an inherited disease characterized by premature onset of aging, increased cancer incidence, and genomic…
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Highly Cited
2000
Highly Cited
2000
Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing*
Baomin Li
,
L. Comai
Journal of Biological Chemistry
2000
Corpus ID: 19813760
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging. The gene responsible for the syndrome…
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Highly Cited
1999
Highly Cited
1999
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.
D. Orren
,
R. Brosh
,
Jan O. Nehlin
,
A. Machwe
,
Matthew D. Gray
,
Vilhelm A. Bohr
Nucleic Acids Research
1999
Corpus ID: 14956722
Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are…
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Highly Cited
1998
Highly Cited
1998
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
Jiang-Cheng Shen
,
M. Gray
,
J. Oshima
,
L. Loeb
Nucleic Acids Research
1998
Corpus ID: 13425685
Werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. The…
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