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WRN protein, human

Known as: Werner Syndrome ATP-Dependent Helicase, RECQ3 protein, human, Werner syndrome helicase, human 
Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP… Expand
National Institutes of Health

Papers overview

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2016
2016
Werner syndrome protein (WRN) is a RecQ helicase that participates in DNA repair, genome stability and cellular senescence. The… Expand
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Highly Cited
2010
Highly Cited
2010
Accurate response to replication arrest is crucial to preserve genome stability and requires both the ATR and ATM functions. The… Expand
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Review
2010
Review
2010
Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated in the maintenance of genome stability… Expand
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Highly Cited
2010
Highly Cited
2010
Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism… Expand
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Highly Cited
2006
Highly Cited
2006
Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitive to DNA interstrand cross-links (ICLs), whose… Expand
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Highly Cited
2006
Highly Cited
2006
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging disorder Werner syndrome (WS… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT A defect in the Werner syndrome protein (WRN) leads to the premature aging disease Werner syndrome (WS). Hallmark… Expand
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Highly Cited
2001
Highly Cited
2001
Werner syndrome (WS) is an inherited disease characterized by premature onset of aging, increased cancer incidence, and genomic… Expand
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Highly Cited
2000
Highly Cited
2000
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging. The gene responsible for the syndrome… Expand
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Highly Cited
1999
Highly Cited
1999
Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are… Expand
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