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WRN protein, human

Known as: Werner Syndrome ATP-Dependent Helicase, RECQ3 protein, human, Werner syndrome helicase, human 
Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP… Expand
National Institutes of Health

Related topics

Related topics

23 relations
3'-5'-ExonucleasesATP HydrolysisAdenosine TriphosphatasesBLM gene
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Broader (1)

Werner Syndrome Helicase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer
Werner syndrome protein (WRN) is a RecQ helicase that participates in DNA repair, genome stability and cellular senescence. The… Expand
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Highly Cited
2010
Highly Cited
2010
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
Accurate response to replication arrest is crucial to preserve genome stability and requires both the ATR and ATM functions. The… Expand
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Review
2010
Review
2010
Roles of Werner syndrome protein in protection of genome integrity.
Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated in the maintenance of genome stability… Expand
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Highly Cited
2010
Highly Cited
2010
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D
Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism… Expand
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Highly Cited
2006
Highly Cited
2006
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitive to DNA interstrand cross-links (ICLs), whose… Expand
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Highly Cited
2006
Highly Cited
2006
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging disorder Werner syndrome (WS… Expand
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Highly Cited
2003
Highly Cited
2003
Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage
ABSTRACT A defect in the Werner syndrome protein (WRN) leads to the premature aging disease Werner syndrome (WS). Hallmark… Expand
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Highly Cited
2001
Highly Cited
2001
Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex*
Werner syndrome (WS) is an inherited disease characterized by premature onset of aging, increased cancer incidence, and genomic… Expand
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Highly Cited
2000
Highly Cited
2000
Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing*
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging. The gene responsible for the syndrome… Expand
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Highly Cited
1999
Highly Cited
1999
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.
Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are… Expand
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