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WRN protein, human
Known as:
Werner Syndrome ATP-Dependent Helicase
, RECQ3 protein, human
, Werner syndrome helicase, human
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Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP…
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National Institutes of Health
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Related topics
Related topics
23 relations
3'-5'-Exonucleases
ATP Hydrolysis
Adenosine Triphosphatases
BLM gene
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Broader (1)
Werner Syndrome Helicase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance.
Sun-Young Lee
,
Hyunwoo Lee
,
Eun-Sun Kim
,
Sojin Park
,
Jiyoen Lee
,
B. Ahn
Mutation research
2015
Corpus ID: 19698468
Review
2015
Review
2015
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review
Jin-Sun Ryu
,
H. Koo
Gerontology
2015
Corpus ID: 19743312
Werner syndrome protein (WRN) is unusual among RecQ family DNA helicases in having an additional exonuclease activity. WRN is…
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2015
2015
The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks
Margaret Tammaro
,
S. Liao
,
Jill E. McCane
,
Hong Yan
Nucleic Acids Research
2015
Corpus ID: 10713107
The first step of homology-dependent repair of DNA double-strand breaks (DSBs) is the resection of the 5′ strand to generate 3…
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2014
2014
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein
Chin-Ju Park
,
J. Ko
,
K. Ryu
,
Byong-Seok Choi
Journal of Biomolecular NMR
2014
Corpus ID: 21582152
RecQ C-terminal (RQC) domain is known as the main DNA binding module of RecQ helicases such as Bloom syndrome protein (BLM) and…
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2011
2011
Cell cycle-regulated association between the Werner syndrome protein and its molecular partners
Sonali P. Jog
,
S. Reddy
,
L. Comai
Cell Cycle
2011
Corpus ID: 29276371
The Werner syndrome protein (WRN) is a nuclear protein with helicase and exonuclease activities, whose loss-of-function mutations…
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2010
2010
Processing of human telomeres by the Werner syndrome protein
S. Reddy
,
Baomin Li
,
L. Comai
Cell Cycle
2010
Corpus ID: 28815752
Comment on: Li B, et al. Aging 2009; 1:289-302.
Highly Cited
2009
Highly Cited
2009
DNA-Dependent Protein Kinase (DNA-PK)–Dependent Cisplatin-Induced Loss of Nucleolar Facilitator of Chromatin Transcription (FACT) and Regulation of Cisplatin Sensitivity by DNA-PK and FACT
J. Dejmek
,
J. D. Iglehart
,
J. Lazaro
Molecular Cancer Research
2009
Corpus ID: 2445110
Both the Ku subunit of the DNA-dependent protein kinase (DNA-PK) and the facilitator of chromatin transcription (FACT) complex…
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2007
2007
Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions*
J. Harrigan
,
J. Piotrowski
,
L. Di Noto
,
R. Levine
,
V. Bohr
Journal of Biological Chemistry
2007
Corpus ID: 41849317
Metal-catalyzed oxidation reactions target amino acids in the metal binding pocket of proteins. Such oxidation reactions…
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Review
2007
Review
2007
Interplay between wrn and the checkpoint in s-phase.
P. Pichierri
Italian Journal of Biochemistry
2007
Corpus ID: 43567631
Stability of the genome is crucial for survival and faithful transmission of the genetic blueprint to progenitors. During DNA…
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Highly Cited
2003
Highly Cited
2003
Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution
W. Cheng
,
C. von Kobbe
,
+4 authors
V. Bohr
Molecular and Cellular Biology
2003
Corpus ID: 4968625
ABSTRACT The Werner syndrome protein (WRN) is a caretaker of the human genome, and the Abl kinase is a regulator of the DNA…
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