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WRN protein, human

Known as: Werner Syndrome ATP-Dependent Helicase, RECQ3 protein, human, Werner syndrome helicase, human 
Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP… 
National Institutes of Health

Related topics

Related topics

23 relations
3'-5'-ExonucleasesATP HydrolysisAdenosine TriphosphatasesBLM gene

Broader (1)

Werner Syndrome Helicase

Papers overview

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2015
2015
WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance.
Review
2015
Review
2015
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review
Werner syndrome protein (WRN) is unusual among RecQ family DNA helicases in having an additional exonuclease activity. WRN is… 
2015
2015
The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks
The first step of homology-dependent repair of DNA double-strand breaks (DSBs) is the resection of the 5′ strand to generate 3… 
2014
2014
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein
RecQ C-terminal (RQC) domain is known as the main DNA binding module of RecQ helicases such as Bloom syndrome protein (BLM) and… 
2011
2011
Cell cycle-regulated association between the Werner syndrome protein and its molecular partners
The Werner syndrome protein (WRN) is a nuclear protein with helicase and exonuclease activities, whose loss-of-function mutations… 
2010
2010
Processing of human telomeres by the Werner syndrome protein
Comment on: Li B, et al. Aging 2009; 1:289-302. 
Highly Cited
2009
Highly Cited
2009
DNA-Dependent Protein Kinase (DNA-PK)–Dependent Cisplatin-Induced Loss of Nucleolar Facilitator of Chromatin Transcription (FACT) and Regulation of Cisplatin Sensitivity by DNA-PK and FACT
Both the Ku subunit of the DNA-dependent protein kinase (DNA-PK) and the facilitator of chromatin transcription (FACT) complex… 
2007
2007
Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions*
Metal-catalyzed oxidation reactions target amino acids in the metal binding pocket of proteins. Such oxidation reactions… 
Review
2007
Review
2007
Interplay between wrn and the checkpoint in s-phase.
Stability of the genome is crucial for survival and faithful transmission of the genetic blueprint to progenitors. During DNA… 
Highly Cited
2003
Highly Cited
2003
Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution
ABSTRACT The Werner syndrome protein (WRN) is a caretaker of the human genome, and the Abl kinase is a regulator of the DNA… 
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