• Publications
  • Influence
Metformin improves healthspan and lifespan in mice
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan andExpand
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Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases*
Werner syndrome is a human premature aging disorder displaying cellular defects associated with telomere maintenance including genomic instability, premature senescence, and accelerated telomereExpand
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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
We have compared the substrate specificities of the BLM and WRN proteins using a variety of partial duplex DNA molecules, which are based upon a common core nucleotide sequence. Expand
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Human RecQ helicases in DNA repair, recombination, and replication.
RecQ helicases are an important family of genome surveillance proteins conserved from bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome maintenance andExpand
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DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than twoExpand
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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
A major cause of cell death caused by genotoxic stress is thought to be due to the depletion of NAD(+) from the nucleus and the cytoplasm. Here we show that NAD(+) levels in mitochondria remain atExpand
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DNA repair deficiency in neurodegeneration
Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic neurons areExpand
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SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have analogous functions,Expand
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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorderExpand
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Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity*
  • R. Brosh, J. Li, +5 authors V. Bohr
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 4 August 2000
Bloom's syndrome is a rare autosomal recessive disorder characterized by genomic instability and predisposition to cancer. BLM, the gene defective in Bloom's syndrome, encodes a 159-kDa proteinExpand
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