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Werner Syndrome Helicase

Known as: RECQ3 Protein, Werner Syndrome RecQ-Like Helicase, Werner Syndrome ATP Dependent Helicase 
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds… Expand
National Institutes of Health

Papers overview

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2016
2016
Significance G-quadruplex (GQ) is a four-stranded DNA structure that forms in the human genome and influences gene expression and… Expand
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Highly Cited
2011
Highly Cited
2011
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used… Expand
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Highly Cited
2005
Highly Cited
2005
The single-stranded DNA-binding protein replication protein A (RPA) interacts with several human RecQ DNA helicases that have… Expand
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Highly Cited
2004
Highly Cited
2004
Werner syndrome (WS) is characterized by features of premature aging and is caused by loss of the RecQ helicase protein WRN. WS… Expand
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Highly Cited
2002
Highly Cited
2002
Werner syndrome is a hereditary premature aging disorder characterized by genome instability. The product of the gene defective… Expand
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Highly Cited
2002
Highly Cited
2002
The loss of function of WRN, a DNA helicase and exonuclease, causes the premature aging disease Werner syndrome. A hallmark… Expand
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Highly Cited
2001
Highly Cited
2001
Werner syndrome (WS) is an inherited disorder characterized by premature aging and genomic instability. The protein encoded by… Expand
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Highly Cited
1999
Highly Cited
1999
While all known natural isolates of C. elegans contain multiple copies of the Tc1 transposon, which are active in the soma, Tc1… Expand
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Highly Cited
1998
Highly Cited
1998
Werner syndrome (WS) is an autosomal recessive disorder characterized by genomic instability and the premature onset of a number… Expand
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Highly Cited
1998
Highly Cited
1998
Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS), a "caricature of aging." We have… Expand
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