Voltage-Gated Sodium Channels

Known as: Voltage-Gated Sodium Channels [Chemical/Ingredient], Sodium Channels, Voltage-Gated, Voltage Gated Sodium Channels 
A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a… (More)
National Institutes of Health

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Papers overview

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Highly Cited
2010
Highly Cited
2010
Molecular identity of dendritic voltage-gated sodium channels.
Active invasion of the dendritic tree by action potentials (APs) generated in the axon is essential for associative synaptic… (More)
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Highly Cited
2008
Highly Cited
2008
The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.
We hypothesized that lacosamide modulates voltage-gated sodium channels (VGSCs) at clinical concentrations (32-100 muM… (More)
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Highly Cited
2007
Highly Cited
2007
BACE1 regulates voltage-gated sodium channels and neuronal activity
BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to… (More)
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Review
2005
Review
2005
Inherited disorders of voltage-gated sodium channels.
A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been… (More)
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Review
2005
Review
2005
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the… (More)
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Review
2005
Review
2005
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.
The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local… (More)
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Highly Cited
2004
Highly Cited
2004
A superfamily of voltage-gated sodium channels in bacteria.
NaChBac, a six-alpha-helical transmembrane-spanning protein cloned from Bacillus halodurans, is the first functionally… (More)
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Review
2003
Review
2003
The role of voltage-gated sodium channels in neuropathic pain
Use-dependent inhibitors of voltage-gated sodium channels (VGSC) are important therapeutic tools for chronic pain management, but… (More)
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Review
2000
Review
2000
From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels
tetrodotoxin binding activity and a protein of ‫072ف‬ kDa (Agnew et al., 1980). Subsequent purification studies showed that the… (More)
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Review
1999
Review
1999
Diversity of mammalian voltage-gated sodium channels.
A variety of different isoforms of mammalian voltage-gated sodium channels have been identified. These channels can be classified… (More)
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