S. Heinemann

Publications310
h-index65
Citations22,454
Highly Influential Citations1,144
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Cloned glutamate receptors.
The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important…
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Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.
TLDR
C-type inactivation is a process influenced by the ionic composition of the external milieu which strongly depends on the amino acid at position 449 in the pore region, and may help to explain the variability in inactivation kinetics observed in the various types of K channels.
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Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
TLDR
It is shown that application of odorants to mammalian cells co-expressing Or22a and Or83b results in non-selective cation currents activated by means of an ionotropic and a metabotropic pathway, and a subsequent increase in the intracellular Ca2+ concentration.
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Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
TLDR
In neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.
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Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
TLDR
A β-subunit (Kvβ1) is cloned that is specifically expressed in the rat nervous system and confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro.
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Molecular cloning and functional expression of glutamate receptor subunit genes.
Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate. The proteins encoded by the individual genes form homomeric ion channels…
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Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
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Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.
TLDR
By analogy to functional aspects of cloned voltage‐gated potassium channels, rectification of HERG, as well as its kinetic properties during the course of an action potential, are presumably governed by a mechanism reminiscent of C‐type inactivation.
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Calcium channel characteristics conferred on the sodium channel by single mutations
TLDR
The effects on ion selectivity of replacing lysine at position 1,422 in repeat III and/or alanine in repeat IV of rat sodium channel II are reported, suggesting that these residues constitute part of the selectivity filter of the channel.
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Ion Conduction through C-Type Inactivated Shaker Channels
TLDR
It is demonstrated that both activation and deactivation can occur in C-type states, although with slower than normal kinetics, and the properties of ion conduction through C- type inactivated channel states are investigated.
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