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Vascular Endothelial Growth Factor Receptor 2, human
Known as:
EC 2.7.1.112
, vascular endothelial growth factor receptor-2, human
, VEGFR2 protein, human
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Vascular endothelial growth factor receptor 2 (1356 aa, ~152 kDa) is encoded by the human KDR gene. This protein is involved in ligand-dependent…
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National Institutes of Health
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Related topics
Related topics
46 relations
AE-941
Angiogenesis Pathway
Angiogenic Process
Cediranib Maleate
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Broader (2)
Protein Tyrosine Kinase
Vascular Endothelial Growth Factor Receptor-2
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
Steven J. Kattman
,
T. Huber
,
G. Keller
Developmental Cell
2006
Corpus ID: 45520620
Highly Cited
2005
Highly Cited
2005
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential.
M. Vodyanik
,
J. Bork
,
J. Thomson
,
I. Slukvin
Blood
2005
Corpus ID: 27084830
Embryonic stem (ES) cells have the potential to serve as an alternative source of hematopoietic precursors for transplantation…
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Highly Cited
2003
Highly Cited
2003
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.
F. Ciardiello
,
R. Caputo
,
+8 authors
G. Tortora
Clinical Cancer Research
2003
Corpus ID: 14235458
PURPOSE Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells and enhances vascular permeability…
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Highly Cited
2001
Highly Cited
2001
Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through…
H. Zeng
,
H. Dvorak
,
D. Mukhopadhyay
Journal of Biological Chemistry
2001
Corpus ID: 19678619
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) achieves its multiple functions by activating two…
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Review
2000
Review
2000
Regulation of angiogenesis via vascular endothelial growth factor receptors.
Tanja Veikkola
,
M. Karkkainen
,
L. Claesson-Welsh
,
K. Alitalo
Cancer Research
2000
Corpus ID: 17210288
Endothelial cell signal transduction mechanisms involved in angiogenesis have come into focus in cancer research when it was…
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Highly Cited
1999
Highly Cited
1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
Tomoko Takahashi
,
H. Ueno
,
M. Shibuya
Oncogene
1999
Corpus ID: 41049787
KDR/Flk-1 tyrosine kinase, one of the two VEGF receptors induces mitogenesis and differentiation of vascular endothelial cells…
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Highly Cited
1998
Highly Cited
1998
Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C*
A. Ristimäki
,
K. Narko
,
B. Enholm
,
V. Joukov
,
K. Alitalo
Journal of Biological Chemistry
1998
Corpus ID: 21536610
Vascular endothelial growth factor (VEGF) is a prime regulator of normal and pathological angiogenesis. Three related endothelial…
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Highly Cited
1997
Highly Cited
1997
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix*
Zoya Poltorak
,
T. Cohen
,
+5 authors
G. Neufeld
Journal of Biological Chemistry
1997
Corpus ID: 22078392
A vascular endothelial growth factor (VEGF) mRNA species containing exons 1-6 and 8 of the VEGF gene was found to be expressed as…
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Highly Cited
1995
Highly Cited
1995
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
Yutaka Takahashi
,
Y. Kitadai
,
C. Bucana
,
K. Cleary
,
L. Ellis
Cancer Research
1995
Corpus ID: 21023454
We studied the correlation between expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF…
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Highly Cited
1995
Highly Cited
1995
Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.
C. Boocock
,
D. Charnock-Jones
,
+5 authors
Stephen K. Smith
Journal of the National Cancer Institute
1995
Corpus ID: 42566805
BACKGROUND Two thirds of patients with ovarian carcinoma have advanced disease at diagnosis and have poor prognoses because of…
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