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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.
Recently, an anti-VEGF antibody (bevacizumab), when used in combination with chemotherapy, was shown to significantly improve survival and response rates in patients with metastatic colorectal cancer and thus, validate VEGF pathway inhibitors as an important new treatment modality in cancer therapy.
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
It is shown that VEGF expression correlates with Stat3 activity in diverse human cancer cell lines and indicates that Stat3 represents a common molecular target for blocking angiogenesis induced by multiple signaling pathways in human cancers.
VEGF-targeted therapy: mechanisms of anti-tumour activity
Several vascular endothelial growth factor (VEGF)-targeted agents, administered either as single agents or in combination with chemotherapy, have been shown to benefit patients with advanced-stage…
Drug development: Raise standards for preclinical cancer research
C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit.
Recurrence and Outcomes Following Hepatic Resection, Radiofrequency Ablation, and Combined Resection/Ablation for Colorectal Liver Metastases
Hepatic resection is the treatment of choice for colorectal liver metastases and RFA alone or in combination with resection for unresectable patients does not provide survival comparable to resection, and provides survival only slightly superior to nonsurgical treatment.
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in…
- R. Fukuda, K. Hirota, F. Fan, Y. Jung, L. Ellis, G. Semenza
- BiologyJournal of Biological Chemistry
- 11 October 2002
It is demonstrated that exposure of HCT116 human colon carcinoma cells to IGF-1 induces the expression of HIF-1α, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene.
Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients.
RFA is a safe, well-tolerated, and effective treatment to achieve tumor destruction in patients with unresectable hepatic malignancies and multimodality treatment approaches that include RFA should be investigated.
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
- Y. Takahashi, Y. Kitadai, C. Bucana, K. Cleary, L. Ellis
- Medicine, BiologyCancer Research
- 15 September 1995
The hypothesis that VEGF is an important angiogenic factor in primary and metastatic human colon cancer is supported and expression and vessel counts may aid in predicting patients at risk for metastasis from colon cancer.
Simplified staging for hepatocellular carcinoma.
The current AJCC staging system for HCC is unnecessarily complex and a simplified model of stratification is proposed based on vascular invasion, tumor number, and tumor size and incorporates the effect of fibrosis on survival.
Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases.
Evaluated patients who underwent preoperative irinotecan- or oxaliplatin-based chemotherapy, followed by resection of colorectal liver metastases found that degree of pathologic response represents a new outcome end point for prognosis after resections of CLM.