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Vascular Endothelial Growth Factor Receptor 2, human

Known as: EC 2.7.1.112, vascular endothelial growth factor receptor-2, human, VEGFR2 protein, human 
Vascular endothelial growth factor receptor 2 (1356 aa, ~152 kDa) is encoded by the human KDR gene. This protein is involved in ligand-dependent… 
National Institutes of Health

Related topics

Related topics

46 relations
AE-941Angiogenesis PathwayAngiogenic ProcessCediranib Maleate

Broader (2)

Protein Tyrosine KinaseVascular Endothelial Growth Factor Receptor-2

Papers overview

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Highly Cited
2006
Highly Cited
2006
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
Highly Cited
2005
Highly Cited
2005
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential.
Embryonic stem (ES) cells have the potential to serve as an alternative source of hematopoietic precursors for transplantation… 
Highly Cited
2003
Highly Cited
2003
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.
PURPOSE Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells and enhances vascular permeability… 
Highly Cited
2001
Highly Cited
2001
Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through…
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) achieves its multiple functions by activating two… 
Review
2000
Review
2000
Regulation of angiogenesis via vascular endothelial growth factor receptors.
Endothelial cell signal transduction mechanisms involved in angiogenesis have come into focus in cancer research when it was… 
Highly Cited
1999
Highly Cited
1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
KDR/Flk-1 tyrosine kinase, one of the two VEGF receptors induces mitogenesis and differentiation of vascular endothelial cells… 
Highly Cited
1998
Highly Cited
1998
Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C*
Vascular endothelial growth factor (VEGF) is a prime regulator of normal and pathological angiogenesis. Three related endothelial… 
Highly Cited
1998
Highly Cited
1998
Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit… 
Highly Cited
1997
Highly Cited
1997
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix*
A vascular endothelial growth factor (VEGF) mRNA species containing exons 1-6 and 8 of the VEGF gene was found to be expressed as… 
Highly Cited
1995
Highly Cited
1995
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
We studied the correlation between expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF… 
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