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VAV1 gene

Known as: vav guanine nucleotide exchange factor 1, VAV1 ONCOGENE, ONCOGENE VAV 
This gene plays a role in signal transduction. It is involved in the development and activation of both B cells and T cells.
National Institutes of Health

Related topics

Related topics

3 relations
B-Cell ActivationSignal TransductionVAV1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer
Many deregulated signal transducer proteins are involved in various cancers at numerous stages of tumor development. One of these… 
2011
2011
Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells
Vav1 is a critical signal transducer for both the development and function of normal hematopoietic cells, in which it regulates… 
2007
2007
Strongly reduced alloreactivity and long‐term survival times of cardiac allografts in Vav1‐ and Vav1/Vav2‐knockout mice
Vav proteins mediate T‐ and B‐cell activation by functioning as GTP/GDP exchange factors for small GTPases. We have studied the… 
Highly Cited
2006
Highly Cited
2006
Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics1
The NK cell-activating receptor NKG2D recognizes several MHC class I-related molecules expressed on virally infected and tumor… 
2006
2006
DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1.
The alpha4beta1 integrin is an essential adhesion molecule for recruitment of circulating lymphocytes into lymphoid organs and… 
2005
2005
Murine γ-Herpesvirus 68 Latency Protein M2 Binds to Vav Signaling Proteins and Inhibits B-cell Receptor-induced Cell Cycle Arrest and Apoptosis in WEHI-231 B Cells*
The MHV-68 latent protein, M2, does not have homology to any known viral or cellular proteins, and its function is unclear. To… 
2004
2004
Differential Regulation of TCR-mediated Gene Transcription by Vav Family Members
Although all three Vav family members are expressed in T lymphocytes, the role that Vav3 plays in T cell activation is poorly… 
2003
2003
Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreading1 2
Vav1 is a 95-kDa member of the Dbl family of guanine exchange factors and a prominent hemopoietic cell-specific protein tyrosine… 
Highly Cited
2002
Highly Cited
2002
Vav1 and Ly-GDI Two Regulators of Rho GTPases, Function Cooperatively as Signal Transducers in T Cell Antigen Receptor-induced Pathways*
The Rho family GTPases are pivotal for T cell signaling; however, the regulation of these proteins is not fully known. One well… 
Highly Cited
2001
Highly Cited
2001
Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells
ABSTRACT The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many… 
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