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VAV1 gene

Known as: vav guanine nucleotide exchange factor 1, VAV1 ONCOGENE, ONCOGENE VAV 
This gene plays a role in signal transduction. It is involved in the development and activation of both B cells and T cells.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown genetic basis, associated with human T… Expand
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Review
2005
Review
2005
  • V. Tybulewicz
  • Current opinion in immunology
  • 2005
  • Corpus ID: 37959410
The Vav family proteins (Vav1, Vav2, Vav3) are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. T… Expand
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Highly Cited
2004
Highly Cited
2004
Natural killer (NK) cells express multiple activating receptors that initiate signaling cascades through DAP10- or immunoreceptor… Expand
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Highly Cited
2003
Highly Cited
2003
The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte… Expand
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Review
2003
Review
2003
Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen… Expand
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Highly Cited
2003
Highly Cited
2003
The guanine nucleotide exchange factor Vav1 regulates actin polymerization and contributes to cytotoxicity by natural killer (NK… Expand
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Highly Cited
2002
Highly Cited
2002
Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND . Integrins induce the formation of large complexes of cytoskeletal and signaling proteins, which regulate many… Expand
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Highly Cited
1996
Highly Cited
1996
p95vav, the product of the vav protooncogene, has been implicated in the T cell receptor (TCR)-mediated signaling cascade p95vav… Expand
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