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VAV1 protein, human

Known as: VAV1 Protein, VAV1 Gene Product, vav 1 oncogene portein, human 
VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and… 
National Institutes of Health

Related topics

Related topics

4 relations
Signal TransductionSignaling Pathway GeneVAV1 gene

Broader (1)

proto-oncogene protein vav

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats
We currently reported that Vav2, a member of the guanine nucleotide exchange factor-Vav subfamily, participates in homocysteine… 
Highly Cited
2002
Highly Cited
2002
Vav1 and Ly-GDI Two Regulators of Rho GTPases, Function Cooperatively as Signal Transducers in T Cell Antigen Receptor-induced Pathways*
The Rho family GTPases are pivotal for T cell signaling; however, the regulation of these proteins is not fully known. One well… 
Highly Cited
2002
Highly Cited
2002
F‐actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts
Following ligand binding the TCR segregates to plasma membrane microdomains, termed lipid rafts, characterized by a highly… 
Highly Cited
2001
Highly Cited
2001
Vav-Rac1-Mediated Activation of the c-Jun N-Terminal Kinase/c-Jun/AP-1 Pathway Plays a Major Role in Stimulation of the Distal NFAT Site in the Interleukin-2 Gene Promoter
ABSTRACT Vav, a hematopoiesis-specific signaling protein, plays an important role in T-cell development and activation. Vav… 
Highly Cited
2000
Highly Cited
2000
The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.
During the interaction of a T cell with an antigen-presenting cell (APC), several receptor ligand pairs, including the T cell… 
Review
1998
Review
1998
Vav links antigen-receptor signaling to the actin cytoskeleton.
The haematopoietic-specific Rho-family guanine-nucleotide exchange factor Vav is a regulator of lymphocyte antigen receptor… 
Highly Cited
1998
Highly Cited
1998
Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.
The T cell-associated CD28 molecule plays a key role in T cell co-stimulation. Its ligation induces the tyrosine phosphorylation… 
Highly Cited
1996
Highly Cited
1996
Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase*
The CD45 family of transmembrane protein-tyrosine phosphatases plays a critical role in T cell activation signaling by regulating… 
Highly Cited
1995
Highly Cited
1995
Interactions between the Protein-tyrosine Kinase ZAP-70, the Proto-oncoprotein Vav, and Tubulin in Jurkat T Cells (*)
Two molecules involved in signal transduction via the T cell antigen receptor, namely the protein-tyrosine kinase ZAP-70 and the… 
Highly Cited
1994
Highly Cited
1994
The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras
CD28 is a 44-kD homodimer expressed on the surface of the majority of human T cells that provides an important costimulus for T… 
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