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V(D)J Recombination

Known as: V-D-J joining, V-D-J recombination, V(D)J Rearrangement 
Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes… 
National Institutes of Health

Related topics

Related topics

49 relations
Cell Differentiation processDCLRE1C geneDCLRE1C wt AlleleG22P1 wt Allele

Papers overview

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Highly Cited
2001
Highly Cited
2001
Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints*
Chromosomal translocations and deletions are among the major events that initiate neoplasia. For lymphoid chromosomal… 
Highly Cited
2001
Highly Cited
2001
Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
Rearrangement of gene segments to generate antigen receptor coding regions depends on the RAG1/2 recombinase, which assembles a… 
Review
1997
Review
1997
IL-7 receptor and VDJ recombination: trophic versus mechanistic actions.
Highly Cited
1996
Highly Cited
1996
Regions of RAG1 protein critical for V(D)J recombination
The products of the recombination activating genes RAG1 and RAG2 are essential for activating V(D)J recombination, and thus are… 
1996
1996
In vitro V(D)J recombination: signal joint formation.
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the… 
Review
1992
Review
1992
Activities involved in V(D)J recombination.
The assembly of Immunoglobulin (Ig) and T cell receptor (TCR) variable region gene segments (V, D, J) is a complex reaction that… 
Highly Cited
1992
Highly Cited
1992
BCL2 oncogene translocation is mediated by a chi-like consensus
Examination of 64 translocations involving the major breakpoint region (mbr) of the BCL2 oncogene and the immunoglobulin heavy… 
1991
1991
Strand breaks without DNA rearrangement in V (D)J recombination
Somatic gene rearrangement of immunoglobulin and T-cell receptor genes [V(D)J recombination] is mediated by pairs of specific DNA… 
Highly Cited
1987
Highly Cited
1987
Developmental stage specificity of the lymphoid V(D)J recombination activity.
We have examined the level of immunoglobulin gene V(D)J recombination activity in a number of cell lines derived from lymphoid or… 
Highly Cited
1987
Highly Cited
1987
T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining
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