V(D)J Recombination

Known as: V-D-J joining, V-D-J recombination, V(D)J Rearrangement 
Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
05010019802018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
S ex chromosomes have evolved independently many times throughout the eukaryotes, and represent a remarkable case of genomic… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Immunoglobulin heavy chain (IgH) variable region exons are assembled from VH, D and JH gene segments in developing B lymphocytes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Antigen receptor genes undergo variable, diversity and joining (V(D)J) recombination, which requires ordered large-scale… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The V(D)J recombination process insures the somatic diversification of immunoglobulin and antigen T cell receptor encoding genes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1996
Highly Cited
1996
THE DNA-dependent protein kinase (DNA-PK) is a mammalian serine/threonine kinase that is implicated in the repair of DNA double… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
The RAG-1 (recombination activating gene-1) genomic locus, which activates V(D)J recombination when introduced into NIH 3T3… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Two conserved DNA sequences serve as joining signals in the assembly of immunoglobulins and T-cell receptors from V-, (D)-, and J… (More)
Is this relevant?