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UGT1A6 gene

Known as: UGT1A6, UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A6, HLUGP 
This gene is involved in the excretion of phenolic metabolites.
National Institutes of Health

Related topics

Related topics

5 relations
UDP-Glucuronosyltransferase 1-6UGT1A LocusUGT1A1 geneUGT1A1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well… 
Highly Cited
2007
Highly Cited
2007
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6
Objectives To explore the possible role of hetero-oligomerization among the human UDP-glucuronosyltransferases in attenuating the… 
2007
2007
Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reaction of a variety of substances. Among the UGT1A… 
Review
2005
Review
2005
UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects.
Highly Cited
2004
Highly Cited
2004
Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity.
The UDP-glucuronosyltransferase (UGT) enzyme 'superfamily' contributes to the metabolism of a myriad of drugs, nondrug xenobiotic… 
Highly Cited
2004
Highly Cited
2004
Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells.
Highly Cited
2003
Highly Cited
2003
Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in…
2001
2001
Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human…
Human UDP-glucuronosyltransferases (UGT, EC 2.4.1.17) involved in the biotransformation of pyrene were investigated by a… 
Highly Cited
2000
Highly Cited
2000
Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
UDP-Glucuronosyltransferases (UGT) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic substrates. The… 
2000
2000
Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7.
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