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UGT1A Locus

Known as: UGT, GNT1, Uridine Phosphate Glycosyltransferase Family 1 Member A Locus 
Human UGT1A gene locus is located in the vicinity of 2q37 and is approximately 188 kb in length. This locus includes nine protein-encoding genes and… 
National Institutes of Health

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2q37UDP-Glucuronosyltransferase 1A1UGT1A geneUGT1A1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not
UDP-glycosyltransferase (UGT) catalyzes the transfer of glycosyl groups (e.g., glucuronic acid) to exogenous or endogenous… 
2013
2013
Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
Background Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased… 
2013
2013
Differences in frequencies of UGT1A9, 1A7, and 1A1 genetic polymorphisms in Chinese Tibetan versus Han Chinese populations.
As part of a series of pharmacogenomics studies of the Chinese population, we investigated genetic polymorphisms of some UGT1A… 
2011
2011
Skp1 Prolyl 4-Hydroxylase of Dictyostelium Mediates Glycosylation-independent and -dependent Responses to O2 without Affecting Skp1 Stability*
Background: GlcNAc capping confounds analysis of prolyl 4-hydroxylation by P4H1 in Dictyostelium O2 sensing. Results: In GlcNAc… 
2010
2010
Effects of Andrographis paniculata and Orthosiphon stamineus Extracts on the Glucuronidation of 4-Methylumbelliferone in Human UGT Isoforms
The effects of Andrographis paniculata and Orthosiphon stamineus extracts on the in vitro glucuronidation of 4… 
2009
2009
Influence of N-Terminal Domain Histidine and Proline Residues on the Substrate Selectivities of Human UDP-Glucuronosyltransferase 1 A 1 , 1 A 6 , 1 A 9 , 2 B 7 , and 2 B 10
An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A… 
2005
2005
Linkage disequilibrium across the UGT1A locus should not be ignored in association studies of cancer susceptibility.
The study by Wang et al. [(1)][1] reported an association between human UGT1A7 gene polymorphisms and hepatocellular carcinoma… 
Highly Cited
2005
Highly Cited
2005
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect… 
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