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UGT1A Locus

Known as: UGT, GNT1, Uridine Phosphate Glycosyltransferase Family 1 Member A Locus 
Human UGT1A gene locus is located in the vicinity of 2q37 and is approximately 188 kb in length. This locus includes nine protein-encoding genes and… 
National Institutes of Health

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11 relations
2q37UDP-Glucuronosyltransferase 1A1UGT1A geneUGT1A1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity
Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level… 
2013
2013
Gender matters: estrogen receptor alpha (ERα) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes…
2011
2011
Skp1 Prolyl 4-Hydroxylase of Dictyostelium Mediates Glycosylation-independent and -dependent Responses to O2 without Affecting Skp1 Stability*
Background: GlcNAc capping confounds analysis of prolyl 4-hydroxylation by P4H1 in Dictyostelium O2 sensing. Results: In GlcNAc… 
2010
2010
Effects of Andrographis paniculata and Orthosiphon stamineus Extracts on the Glucuronidation of 4-Methylumbelliferone in Human UGT Isoforms
The effects of Andrographis paniculata and Orthosiphon stamineus extracts on the in vitro glucuronidation of 4… 
Review
2008
Review
2008
Family 1 uridine-5′-diphosphate glucuronosyltransferases (UGT1A): from Gilbert’s syndrome to genetic organization and variability
The human UDP-glucuronosyltransferase 1A gene locus is organized to generate enzymes, which share a carboxyterminal portion and… 
2006
2006
Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus
UDP‐Glucuronosyltransferases (UGTs) are a superfamily of enzymes responsible for glucuronidation of xenobiotics and endobiotics… 
2005
2005
Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide.
Highly Cited
1994
Highly Cited
1994
A New Type of Defect in the Gene for Bilirubin Uridine 5 '-Diphosphate-Glucuronosyltransferase in a Patient with Crigler-Najjar Syndrome Type I
ABSTRACT: Crigler-Najjar syndrome (CN) type I, which is characterized by the complete absence of bilirubin uridine 5'-diphosphate… 
Highly Cited
1993
Highly Cited
1993
Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II.
Crigler-Najjar syndrome (CN) type II is characterized by severe chronic nonhemolytic unconjugated hyperbilirubinemia due to… 
1990
1990
Chromosomal mapping of a human phenol UDP‐glucuronosyltransferase, GNT1
A 5' fragment of a full‐length cDNA clone encoding a human phenol UDP‐glucuronosyltransferase was used to produce a specific… 
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