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UGT1A1 gene

Known as: UDP Glycosyltransferase 1 Family, Polypeptide A1 Gene, UDP-GLYCOSYLTRANSFERASE 1, UDP glucuronosyltransferase family 1 member A1 
This gene is involved in controlling serum levels of bilirubin and in glucuronidation.
National Institutes of Health

Related topics

Related topics

10 relations
Estrogen Metabolic ProcessUDP-Glucuronosyltransferase 1A1UGT1A LocusUGT1A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Comparison of effects of UGT1A1*6 and UGT1A1*28 on irinotecan-induced adverse reactions in the Japanese population: analysis of the Biobank Japan Project
It has been reported that there are differences in effects on irinotecan-induced adverse reactions between UGT1A1*6 and UGT1A1*28… 
2018
2018
Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma
We investigated the relationship between axitinib pharmacogenetics and clinical efficacy/adverse events in advanced renal cell… 
2013
2013
UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI‐treated metastatic colorectal cancer in two prospective studies in Japan
Retrospective studies have suggested that UDP‐glucuronosyltransferase (UGT)1A1, UGT1A7, and UGT1A9 predict severe toxicity and… 
2013
2013
Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.
The oligomerization of UGTs [UDP (uridine diphosphate)-glucuronosyltransferases] modulates their enzyme activities. Recent… 
2010
2010
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation.
Review
2009
Review
2009
Pharmacogenomics and -genetics in colorectal cancer.
2006
2006
[Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women].
Estrogens are critical for breast cancer initiation and development. Sulfotransferase 1A1 (SULT1A1) and UDP… 
2006
2006
Association of SULT1A1 and UGT1A1 polymorphisms with breast cancer risk and phenotypes in Russian women
Estrogens are critical for breast cancer initiation and development. Sulfotransferase 1A1 (SULT1A1) and UDP… 
2001
2001
Role of UGT1A1 mutation in fasting hyperbilirubinemia
Low‐grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high‐grade fasting… 
Highly Cited
2000
Highly Cited
2000
Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
UDP-Glucuronosyltransferases (UGT) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic substrates. The… 
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