UGT1A1 gene

Known as: UDP Glycosyltransferase 1 Family, Polypeptide A1 Gene, UDP-GLYCOSYLTRANSFERASE 1, UDP glucuronosyltransferase family 1 member A1 
This gene is involved in controlling serum levels of bilirubin and in glucuronidation.
National Institutes of Health

Papers overview

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2014
2014
A meta-analysis in Caucasians was conducted to investigate the possible association of uridine diphosphate… (More)
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2012
2012
Natural variation in human skin pigmentation is primarily due to genetic causes rooted in recent evolutionary history. Genetic… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE A previous meta-analysis showed that the association between the UGT1A1*28 genotype and irinotecan-induced neutropenia… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity outcome of irinotecan-treated patients. We… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Irinotecan (CPT-11) is approved in metastatic colorectal cancer treatment and can cause severe toxicity. The main purpose… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE To determine whether uridine diphosphate-glucuronosyltransferase 1A1, UGT1A7, and UGT1A9 polymorphisms affect the… (More)
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Highly Cited
2002
Highly Cited
2002
7-Ethyl-10-hydroxycamptothecin (SN-38) is the pharmacologically active metabolite of irinotecan, in addition to being responsible… (More)
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Review
2000
Highly Cited
1999
Highly Cited
1999
BACKGROUND Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1 (UGT1A1) is primarily responsible for the… (More)
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Highly Cited
1999
Highly Cited
1999
Polymorphisms that alter UDP-glucuronosyltransferase (UGT) activities have been identified. Mutations in the promoter of the… (More)
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