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UGT1A1 gene

Known as: UDP Glycosyltransferase 1 Family, Polypeptide A1 Gene, UDP-GLYCOSYLTRANSFERASE 1, UDP glucuronosyltransferase family 1 member A1 
This gene is involved in controlling serum levels of bilirubin and in glucuronidation.
National Institutes of Health

Related topics

Related topics

10 relations
Estrogen Metabolic ProcessUDP-Glucuronosyltransferase 1A1UGT1A LocusUGT1A gene

Papers overview

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2018
2018
Relevance of CYP 3 A 4 * 20 , UGT 1 A 1 * 37 and UGT 1 A 1 * 28 variants in irinotecan-induced severe toxicity Running title : genetic biomarkers of irinotecan toxicity
2017
2017
Combined DPD and UGT1A1 Mutation in a Single Patient: A Case Report
Pharmacogenetic studies on 5-FU have mostly focused on enzyme Dihydropyrimidine Dehydrogenase (DPD), which is a rate-limiting… 
2016
2016
Effects of UGT1A1*6, UGT1A1*28, and ABCB1-3435C>T polymorphisms on irinotecan induced toxicity in Chinese cancer patients.
OBJECT The aim of this study was to investigate whether UGT1A1*6/*28 or ABCB1-3435C>T polymorphisms affect irinotecan-induced… 
2016
2016
Hepatic expression of transcription factors affecting developmental regulation of UGT1A1 in the Han Chinese population
Complete or partial inactivity of UGT1A1, the unique enzyme responsible for bilirubin glucuronidation, is commonly associated… 
2014
2014
Relationship of UGT1A1 and 2B7 Gene Polymorphism with Colorectal Cancer
Objective To study the allelic frequency of UGT1A1 and UGT2B7 genes,and the relationship between the mutations of UGT1A1 and… 
2011
2011
Generation of biological association networks: A novel strategy to detect new targets in cancer therapy
The aim of this work was to design a novel strategy to detect new targets for anticancer treatments. The rationale was to build… 
2009
2009
IRINOTECANTOXICITY RELATED TO GILBERT´S SYNDROME - COMPARISON OF THREE METHODS FOR GENOTYPING OF UGT1A1 (TA)n
Gilbert’s syndrome (GS) occurs in approximately 10% of the European population. The most common cause is homozygosity for UGT1A1… 
2009
2009
UGT 1 A 10 is Responsible for SN-38 Glucuronidation and its Expression in Human Lung Cancers
Background: We previously reported that upregulation of glucuronidation activity catalyzed by uridine 5… 
2008
2008
尿甘雙磷酸葡萄糖醛酸基轉移脢基因多型性和肺癌相關性研究(II)- UGT1A 基因之協同作用相關性研究
2006
2006
[Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women].
Estrogens are critical for breast cancer initiation and development. Sulfotransferase 1A1 (SULT1A1) and UDP…